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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (273 aa)    
Predicted Functional Partners:
AEB83802.1
TIGRFAM: Protein-L-isoaspartate(D-aspartate) O-methyltransferase; KEGG: dia:Dtpsy_1081 protein-L-isoaspartate O-methyltransferase; PFAM: Protein-L-isoaspartate(D-aspartate) O-methyltransferase.
  
 0.961
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
    
 0.953
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.942
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
 
  
 0.942
AEB84027.1
PFAM: NUDIX hydrolase domain; KEGG: dia:Dtpsy_2385 NUDIX hydrolase.
 
 
  0.931
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.930
AEB83219.1
Deoxyguanosinetriphosphate triphosphohydrolase-like protein; SMART: Metal-dependent phosphohydrolase, HD domain; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; KEGG: ajs:Ajs_0736 deoxyguanosinetriphosphate triphosphohydrolase-like protein; HAMAP: Deoxyguanosinetriphosphate triphosphohydrolase, type 2; PFAM: Metal-dependent phosphohydrolase, HD subdomain; Belongs to the dGTPase family. Type 2 subfamily.
 
  
 0.928
purH
Bifunctional purine biosynthesis protein purH; KEGG: dia:Dtpsy_2907 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: AICARFT/IMPCHase bienzyme; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain.
     
 0.928
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
 
  
 0.925
AEB86890.1
TIGRFAM: Adenylosuccinate lyase; KEGG: dia:Dtpsy_3376 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal/plant; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.925
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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