Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEB84174.1PFAM: Abortive phage infection; KEGG: pph:Ppha_0341 hypothetical protein. (596 aa)    
Predicted Functional Partners:
AEB84172.1
PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; KEGG: eba:ebA2417 hypothetical protein.
 
     0.943
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.928
parC
DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
  
 
 0.928
AEB84173.1
PFAM: DNA methylase N-4/N-6; KEGG: bpm:BURPS1710b_3656 adenine specific DNA methylase Mod.
 
   
 0.892
AEB84177.1
Manually curated; PFAM: SNF2-related; Helicase, C-terminal; KEGG: tbd:Tbd_0933 DEAD/DEAH box helicase; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal.
 
 
 0.890
AEB84175.1
PFAM: Peptidase S8/S53, subtilisin/kexin/sedolisin; KEGG: alv:Alvin_2786 peptidase S8 and S53 subtilisin kexin sedolisin.
     
 0.783
AEB82551.1
TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase, ATP-dependent, RecQ type; PFAM: RQC domain; Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase/RNase D C-terminal, HRDC domain; KEGG: dia:Dtpsy_0103 ATP-dependent DNA helicase RecQ; SMART: RQC domain; Helicase, C-terminal; DEAD-like helicase, N-terminal; Helicase/RNase D C-terminal, HRDC domain.
  
 
 0.730
AEB84122.1
KEGG: tmz:Tmz1t_1007 hypothetical protein.
  
     0.703
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
 0.682
AEB84112.1
KEGG: tmz:Tmz1t_1021 hypothetical protein.
  
     0.681
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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