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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
phnCPhosphonate ABC transporter, ATPase subunit; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (265 aa)    
Predicted Functional Partners:
AEB84363.1
TIGRFAM: Phosphonate-binding periplasmic protein; KEGG: mms:mma_3041 phosphonate ABC-type transport system substrate-binding protein.
 
 
 0.997
AEB84362.1
Phosphonate ABC transporter, inner membrane subunit; KEGG: mms:mma_3042 phosphonate ABC-type transport system permease protein; TIGRFAM: Phosphonate uptake transporter; PFAM: Binding-protein-dependent transport systems inner membrane component.
 
 
 0.993
AEB84361.1
KEGG: bvi:Bcep1808_7212 phosphonate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain.
 
   
 0.832
AEB84584.1
KEGG: dia:Dtpsy_2282 transcriptional regulator, GntR family; PFAM: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SMART: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR.
  
  
 0.822
AEB83341.1
Histidine kinase; KEGG: dar:Daro_2490 sensor histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain.
  
  
 0.798
prfC
Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
      
 0.637
AEB84360.1
PFAM: LysR, substrate-binding; HTH transcriptional regulator, LysR; KEGG: bvi:Bcep1808_7210 LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
       0.628
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.601
AEB84932.1
PFAM: Domain of unknown function DUF214, ABC transporter permease; KEGG: dia:Dtpsy_2312 protein of unknown function DUF214.
 
      0.576
flhC
Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family.
      
 0.497
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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