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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB84763.1KEGG: dia:Dtpsy_1640 iron-sulfur cluster assembly protein IscA; TIGRFAM: ISC system FeS cluster assembly, IscA scaffold; FeS cluster insertion; PFAM: FeS cluster biogenesis; Belongs to the HesB/IscA family. (107 aa)    
Predicted Functional Partners:
hscB
Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.989
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.978
AEB84762.1
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
  
 0.977
AEB84766.1
KEGG: dia:Dtpsy_1643 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin.
 
 
 0.967
AEB84760.1
KEGG: dia:Dtpsy_1637 transcriptional regulator, BadM/Rrf2 family; TIGRFAM: ISC system FeS cluster assembly, IscR transcription factor; Transcription regulator Rrf2; PFAM: Transcription regulator Rrf2.
  
  
 0.889
AEB84958.1
FeS assembly protein SufB; KEGG: dia:Dtpsy_2343 cysteine desulfurase activator complex subunit SufB; TIGRFAM: SUF system FeS cluster assembly, SufB; PFAM: SUF system FeS cluster assembly, SufBD.
  
 
 0.877
hscA
Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 
 0.850
AEB84954.1
KEGG: dia:Dtpsy_2339 SUF system FeS assembly protein, NifU family; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold; PFAM: NIF system FeS cluster assembly, NifU, N-terminal.
  
  
 0.817
AEB84957.1
TIGRFAM: ATPase SufC, SUF system FeS cluster assembly; PFAM: ABC transporter-like; KEGG: dia:Dtpsy_2342 FeS assembly ATPase SufC; SMART: ATPase, AAA+ type, core.
  
 
 0.739
AEB84343.1
KEGG: ajs:Ajs_1664 BadM/Rrf2 family transcriptional regulator; TIGRFAM: Transcription regulator Rrf2; PFAM: Transcription regulator Rrf2.
  
  
 0.702
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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