Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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AEB84781.1KEGG: dia:Dtpsy_1659 dihydrolipoamide dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Biotin/lipoyl attachment; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (609 aa)    
Predicted Functional Partners:
AEB83010.1
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: pol:Bpro_0274 branched-chain alpha-keto acid dehydrogenase E1 component; SMART: Transketolase-like, pyrimidine-binding domain.
 
 0.999
AEB84779.1
2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.999
AEB85373.1
2-oxoglutarate dehydrogenase, E1 subunit; SMART: Transketolase-like, pyrimidine-binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; KEGG: ajs:Ajs_1822 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component.
  
 0.999
AEB84661.1
2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.998
AEB84892.1
Pyruvate dehydrogenase (acetyl-transferring); PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: rfr:Rfer_3966 transketolase; SMART: Transketolase-like, pyrimidine-binding domain.
 
 0.996
AEB83009.1
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); KEGG: pol:Bpro_0273 branched-chain alpha-keto acid dehydrogenase E1 component; PFAM: Dehydrogenase, E1 component; 2-oxoisovalerate dehydrogenase, E1 alpha subunit, N-terminal.
 
 0.995
AEB84780.1
Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
0.994
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.990
AEB84899.1
TIGRFAM: Glycine cleavage system T protein; KEGG: xtr:100488488 hypothetical protein LOC100488488; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel.
 
 0.987
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.986
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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