Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
AEB84840.1TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; Methylmalonyl-CoA mutase, C-terminal; KEGG: dia:Dtpsy_1849 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; Cobalamin (vitamin B12)-binding. (713 aa)    
Predicted Functional Partners:
AEB84841.1
LAO/AO transport system ATPase; KEGG: xtr:100495832 uncharacterized protein CC_2483-like; TIGRFAM: ArgK protein; PFAM: ArgK protein.
 0.999
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.956
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.948
AEB82510.1
TIGRFAM: Succinate CoA transferase; KEGG: ajs:Ajs_0046 acetyl-CoA hydrolase; PFAM: Acetyl-CoA hydrolase/transferase.
 
 
 0.943
AEB84842.1
Propionyl-CoA carboxylase; KEGG: ajs:Ajs_2042 carboxyl transferase; PFAM: Carboxyl transferase.
 
  
 0.932
AEB83521.1
o-succinylbenzoate--CoA ligase; KEGG: dia:Dtpsy_0996 malonyl-CoA synthase; PFAM: AMP-dependent synthetase/ligase.
    
 0.907
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
    
 0.881
AEB84475.1
TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; KEGG: ajs:Ajs_1635 methylcitrate synthase; PFAM: Citrate synthase-like; Belongs to the citrate synthase family.
    
 0.870
AEB84578.1
KEGG: dia:Dtpsy_2288 type II citrate synthase; TIGRFAM: Citrate synthase, type II; PFAM: Citrate synthase-like; Belongs to the citrate synthase family.
    
 0.870
AEB84780.1
Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.831
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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