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[Homology]
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hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa)    
Predicted Functional Partners:
hisB
KEGG: dia:Dtpsy_0730 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase.
  
 0.984
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.974
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.971
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.964
hisA
TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; KEGG: ajs:Ajs_0765 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis.
 
  
 0.956
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.952
hisC
PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dia:Dtpsy_0729 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.946
hisE
KEGG: dia:Dtpsy_0740 phosphoribosyl-ATP pyrophosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like.
 
  
 0.903
hisC-2
TIGRFAM: Histidinol-phosphate aminotransferase; KEGG: vap:Vapar_1479 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.890
AEB84864.1
PFAM: Short-chain dehydrogenase/reductase SDR; KEGG: bxe:Bxe_C0308 putative short-chain dehydrogenase/reductase; SMART: Polyketide synthase/Fatty acid synthase, KR.
 
 
 
 0.836
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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