Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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AEB85264.1methylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (175 aa)    
Predicted Functional Partners:
AEB85263.1
DNA repair protein and transcriptional regulator, AraC family; KEGG: ajs:Ajs_2020 DNA-O6-methylguanine--protein-cysteine S-methyltransferase.
  
 0.949
AEB85265.1
PFAM: Drug/metabolite transporter; KEGG: dia:Dtpsy_1827 protein of unknown function DUF6 transmembrane.
       0.842
AEB84679.1
DNA-3-methyladenine glycosylase II; SMART: HhH-GPD domain; manually curated; KEGG: dia:Dtpsy_2090 HhH-GPD family protein; PFAM: HhH-GPD domain.
 
  
 0.841
AEB82910.1
KEGG: ajs:Ajs_0457 DNA-3-methyladenine glycosylase I; PFAM: Methyladenine glycosylase.
   
 0.752
AEB86067.1
KEGG: dia:Dtpsy_2749 hypothetical protein.
 
  
 0.673
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.520
AEB82442.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.468
AEB85262.1
Transcriptional regulator, RpiR family; PFAM: Sugar isomerase (SIS); Helix-turn-helix protein RpiR; KEGG: dac:Daci_0986 RpiR family transcriptional regulator.
       0.460
AEB86190.1
UspA domain-containing protein; PFAM: UspA; Haemerythrin/HHE cation-binding motif; KEGG: reu:Reut_B3843 hypothetical protein.
  
  
 0.432
AEB83362.1
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
 
   
 0.426
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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