| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEB83598.1 | AEB85324.1 | Alide2_1194 | Alide2_2977 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | 0.432 |
| AEB83598.1 | clpP | Alide2_1194 | Alide2_1459 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.536 |
| AEB83598.1 | clpX | Alide2_1194 | Alide2_1460 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.475 |
| AEB83598.1 | cmk | Alide2_1194 | Alide2_1977 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.449 |
| AEB83598.1 | thyA | Alide2_1194 | Alide2_1447 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.439 |
| AEB84354.1 | AEB85324.1 | Alide2_1979 | Alide2_2977 | Chorismate mutase; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; KEGG: dia:Dtpsy_1394 chorismate mutase; SMART: Chorismate mutase. | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | 0.489 |
| AEB84354.1 | cmk | Alide2_1979 | Alide2_1977 | Chorismate mutase; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; KEGG: dia:Dtpsy_1394 chorismate mutase; SMART: Chorismate mutase. | Cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.992 |
| AEB84354.1 | pheT | Alide2_1979 | Alide2_2825 | Chorismate mutase; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; KEGG: dia:Dtpsy_1394 chorismate mutase; SMART: Chorismate mutase. | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: ajs:Ajs_2395 phenylalanyl-tRNA synthetase subunit beta; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.604 |
| AEB85324.1 | AEB83598.1 | Alide2_2977 | Alide2_1194 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.432 |
| AEB85324.1 | AEB84354.1 | Alide2_2977 | Alide2_1979 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Chorismate mutase; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; KEGG: dia:Dtpsy_1394 chorismate mutase; SMART: Chorismate mutase. | 0.489 |
| AEB85324.1 | AEB85325.1 | Alide2_2977 | Alide2_2978 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Protein of unknown function DUF2309; PFAM: Uncharacterised protein family UPF0753; KEGG: mei:Msip34_2093 hypothetical protein; Belongs to the UPF0753 family. | 0.598 |
| AEB85324.1 | AEB85326.1 | Alide2_2977 | Alide2_2979 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | NADH/Ubiquinone/plastoquinone (complex I); PFAM: NADH:ubiquinone/plastoquinone oxidoreductase; KEGG: mei:Msip34_2092 NADH dehydrogenase subunit L. | 0.559 |
| AEB85324.1 | clpP | Alide2_2977 | Alide2_1459 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.732 |
| AEB85324.1 | clpX | Alide2_2977 | Alide2_1460 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.772 |
| AEB85324.1 | cmk | Alide2_2977 | Alide2_1977 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.442 |
| AEB85324.1 | hemH-2 | Alide2_2977 | Alide2_2976 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.566 |
| AEB85324.1 | pheT | Alide2_2977 | Alide2_2825 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: ajs:Ajs_2395 phenylalanyl-tRNA synthetase subunit beta; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.456 |
| AEB85324.1 | thyA | Alide2_2977 | Alide2_1447 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.796 |
| AEB85325.1 | AEB85324.1 | Alide2_2978 | Alide2_2977 | Protein of unknown function DUF2309; PFAM: Uncharacterised protein family UPF0753; KEGG: mei:Msip34_2093 hypothetical protein; Belongs to the UPF0753 family. | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: mxa:MXAN_6138 riboflavin biosynthesis protein RibD domain-containing protein. | 0.598 |
| AEB85325.1 | AEB85326.1 | Alide2_2978 | Alide2_2979 | Protein of unknown function DUF2309; PFAM: Uncharacterised protein family UPF0753; KEGG: mei:Msip34_2093 hypothetical protein; Belongs to the UPF0753 family. | NADH/Ubiquinone/plastoquinone (complex I); PFAM: NADH:ubiquinone/plastoquinone oxidoreductase; KEGG: mei:Msip34_2092 NADH dehydrogenase subunit L. | 0.992 |