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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lapBTetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (385 aa)    
Predicted Functional Partners:
AEB85599.1
PFAM: Protein of unknown function DUF1049; KEGG: dia:Dtpsy_1389 hypothetical protein.
 
   
 0.898
AEB85601.1
KEGG: ajs:Ajs_2473 hypothetical protein.
       0.837
lptD
LPS-assembly protein lptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
 
   
 0.692
AEB85602.1
NADH dehydrogenase (quinone); KEGG: dia:Dtpsy_1386 putative monovalent cation/H+ antiporter subunit A; PFAM: NADH:ubiquinone/plastoquinone oxidoreductase; Na+/H+ antiporter MnhB subunit-related protein.
       0.609
lpxH
Metallophosphoesterase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.602
AEB86153.1
KEGG: ajs:Ajs_3641 hypothetical protein.
 
     0.567
AEB85603.1
PFAM: NADH-ubiquinone oxidoreductase chain 4L/K; KEGG: dia:Dtpsy_1385 putative monovalent cation/H+ antiporter subunit C.
       0.564
AEB84727.1
KEGG: dia:Dtpsy_1724 permease YjgP/YjgQ family protein; manually curated; PFAM: Permease YjgP/YjgQ, predicted.
 
     0.550
ftsB
Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
 
     0.532
AEB85744.1
PFAM: Colicin V production, CvpA; Protein of unknown function DUF2474; KEGG: dia:Dtpsy_2227 colicin V production protein.
 
   
 0.526
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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