Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEB85843.1DnaA regulatory inactivator Hda; KEGG: aav:Aave_1971 chromosomal replication initiator, DnaA; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. (235 aa)    
Predicted Functional Partners:
AEB82442.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.968
pcnB
poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
 
 
 
 0.890
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 
 
 0.853
AEB85840.1
TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: ajs:Ajs_2990 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
     
 0.849
AEB85842.1
TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: dia:Dtpsy_2419 HAD-superfamily subfamily IB hydrolase, TIGR01490.
       0.818
AEB83731.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
  
 
 0.780
glyQ
TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; KEGG: dac:Daci_1288 glycyl-tRNA synthetase subunit alpha; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit.
  
    0.581
purM
TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: ajs:Ajs_2994 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein.
  
  
 0.555
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
  
   
 0.515
AEB85536.1
KEGG: ajs:Ajs_1718 DNA-directed DNA polymerase.
 
  
 0.515
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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