STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (615 aa)    
Predicted Functional Partners:
AEB85448.1
TIGRFAM: Phosphomethylpyrimidine kinase type-2; KEGG: ajs:Ajs_1787 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 
 0.989
AEB86203.1
PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: dia:Dtpsy_2903 phosphomethylpyrimidine kinase type-1.
  
 
 0.985
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.983
AEB85452.1
KEGG: dia:Dtpsy_1939 thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase.
 
  
 0.955
AEB85450.1
KEGG: dia:Dtpsy_1937 thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS.
  
  
 0.929
purM
TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: ajs:Ajs_2994 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein.
    
 0.815
AEB83403.1
PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: ajs:Ajs_3507 UBA/ThiF-type NAD/FAD binding protein.
 
  
 0.806
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
    
  0.806
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.763
AEB85629.1
PRTRC system ThiF family protein; KEGG: ajs:Ajs_1597 UBA/ThiF-type NAD/FAD binding protein; TIGRFAM: ParB-related, ThiF-related cassette, ThiF; PFAM: UBA/THIF-type NAD/FAD binding fold.
  
  
 0.723
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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