| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEB83598.1 | AEB84493.1 | Alide2_1194 | Alide2_2121 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | 0.947 |
| AEB83598.1 | AEB85031.1 | Alide2_1194 | Alide2_2674 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.732 |
| AEB83598.1 | AEB85840.1 | Alide2_1194 | Alide2_3512 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: ajs:Ajs_2990 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 0.763 |
| AEB83598.1 | AEB86045.1 | Alide2_1194 | Alide2_3720 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: ajs:Ajs_3398 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. | 0.693 |
| AEB83598.1 | AEB86955.1 | Alide2_1194 | Alide2_4653 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: ajs:Ajs_4077 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | 0.999 |
| AEB83598.1 | panB | Alide2_1194 | Alide2_1009 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.695 |
| AEB83598.1 | panC | Alide2_1194 | Alide2_1008 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.750 |
| AEB83598.1 | ribB | Alide2_1194 | Alide2_2258 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| AEB83598.1 | ribH | Alide2_1194 | Alide2_2257 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.992 |
| AEB84493.1 | AEB83598.1 | Alide2_2121 | Alide2_1194 | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.947 |
| AEB84493.1 | AEB86045.1 | Alide2_2121 | Alide2_3720 | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: ajs:Ajs_3398 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. | 0.930 |
| AEB84493.1 | AEB86955.1 | Alide2_2121 | Alide2_4653 | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: ajs:Ajs_4077 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | 0.912 |
| AEB84493.1 | ribB | Alide2_2121 | Alide2_2258 | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.478 |
| AEB84493.1 | ribH | Alide2_2121 | Alide2_2257 | KEGG: dac:Daci_2563 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.908 |
| AEB85031.1 | AEB83598.1 | Alide2_2674 | Alide2_1194 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.732 |
| AEB85031.1 | AEB85840.1 | Alide2_2674 | Alide2_3512 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: ajs:Ajs_2990 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 0.999 |
| AEB85031.1 | AEB86045.1 | Alide2_2674 | Alide2_3720 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: ajs:Ajs_3398 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. | 0.416 |
| AEB85031.1 | AEB86955.1 | Alide2_2674 | Alide2_4653 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: ajs:Ajs_4077 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | 0.615 |
| AEB85031.1 | panB | Alide2_2674 | Alide2_1009 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.607 |
| AEB85031.1 | panC | Alide2_2674 | Alide2_1008 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.672 |