MYOZ1 protein (Taeniopygia guttata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MYOZ1

Myozenin 1. (294 aa)

Predicted Functional Partners:

ACTN2

0.886

TNNC2

0.809

MYOT

0.775

TCAP

0.714

SLN

0.664

TNNI2

0.640

LOC105759663

0.627

ENSTGUP00000034692

0.627

ACTN1

0.627

AMPD1

0.620

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	MYOZ1	ENSTGUP00000036000	ENSTGUP00000007234	Actinin alpha 1.	Myozenin 1.	0.627
ACTN1	TCAP	ENSTGUP00000036000	ENSTGUP00000023683	Actinin alpha 1.	Telethonin.	0.446
ACTN1	TNNC2	ENSTGUP00000036000	ENSTGUP00000006341	Actinin alpha 1.	Troponin C2, fast skeletal type.	0.520
ACTN1	TNNI2	ENSTGUP00000036000	ENSTGUP00000038385	Actinin alpha 1.	Troponin I2, fast skeletal type.	0.613
ACTN2	AMPD1	ENSTGUP00000010782	ENSTGUP00000001026	Actinin alpha 2.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.413
ACTN2	MYOT	ENSTGUP00000010782	ENSTGUP00000001228	Actinin alpha 2.	Myotilin.	0.540
ACTN2	MYOZ1	ENSTGUP00000010782	ENSTGUP00000007234	Actinin alpha 2.	Myozenin 1.	0.886
ACTN2	TCAP	ENSTGUP00000010782	ENSTGUP00000023683	Actinin alpha 2.	Telethonin.	0.667
ACTN2	TNNC2	ENSTGUP00000010782	ENSTGUP00000006341	Actinin alpha 2.	Troponin C2, fast skeletal type.	0.724
ACTN2	TNNI2	ENSTGUP00000010782	ENSTGUP00000038385	Actinin alpha 2.	Troponin I2, fast skeletal type.	0.783
AMPD1	ACTN2	ENSTGUP00000001026	ENSTGUP00000010782	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Actinin alpha 2.	0.413
AMPD1	MYOZ1	ENSTGUP00000001026	ENSTGUP00000007234	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Myozenin 1.	0.620
ENSTGUP00000034692	MYOZ1	ENSTGUP00000034692	ENSTGUP00000007234	annotation not available	Myozenin 1.	0.627
ENSTGUP00000034692	TCAP	ENSTGUP00000034692	ENSTGUP00000023683	annotation not available	Telethonin.	0.446
ENSTGUP00000034692	TNNC2	ENSTGUP00000034692	ENSTGUP00000006341	annotation not available	Troponin C2, fast skeletal type.	0.520
ENSTGUP00000034692	TNNI2	ENSTGUP00000034692	ENSTGUP00000038385	annotation not available	Troponin I2, fast skeletal type.	0.613
LOC105759663	MYOZ1	ENSTGUP00000032518	ENSTGUP00000007234	Alpha-actinin-4.	Myozenin 1.	0.627
LOC105759663	TCAP	ENSTGUP00000032518	ENSTGUP00000023683	Alpha-actinin-4.	Telethonin.	0.446
LOC105759663	TNNC2	ENSTGUP00000032518	ENSTGUP00000006341	Alpha-actinin-4.	Troponin C2, fast skeletal type.	0.520
LOC105759663	TNNI2	ENSTGUP00000032518	ENSTGUP00000038385	Alpha-actinin-4.	Troponin I2, fast skeletal type.	0.613

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.728

expected number of edges:

14

PPI enrichment p-value:

3.99e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

4 of 62

2.02

2.15

4.11e-05

GO:0070828

Heterochromatin organization

4 of 68

1.98

2.1

4.74e-05

GO:0050872

White fat cell differentiation

3 of 22

2.34

1.97

0.00019

GO:0045444

Fat cell differentiation

4 of 124

1.72

1.59

0.00034

GO:0006325

Chromatin organization

7 of 523

1.34

1.54

1.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001222

Transcription corepressor binding

6 of 58

2.22

4.11

2.51e-09

GO:0042826

Histone deacetylase binding

4 of 130

1.7

1.55

0.00040

GO:0098882

Structural constituent of presynaptic active zone

2 of 6

2.73

1.51

0.0018

GO:0051287

NAD binding

3 of 64

1.88

1.39

0.0016

GO:0008134

Transcription factor binding

7 of 660

1.24

1.35

3.15e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035098

ESC/E(Z) complex

4 of 12

2.73

3.71

1.20e-07

GO:0016581

NuRD complex

4 of 18

2.56

3.42

3.22e-07

GO:0017053

Transcription repressor complex

5 of 82

2.0

2.96

3.76e-07

GO:0005667

Transcription regulator complex

10 of 518

1.5

2.86

8.60e-12

GO:0016589

NURF complex

3 of 8

2.78

2.8

6.96e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7538

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Histone methyltransferase activity (H3-K9 specific)

4 of 7

2.97

3.81

1.01e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05220

Chronic myeloid leukemia

6 of 87

2.05

3.82

2.68e-09

map04330

Notch signaling pathway

4 of 69

1.97

2.31

1.45e-05

map05200

Pathways in cancer

6 of 558

1.24

1.33

4.55e-05

map04310

Wnt signaling pathway

3 of 205

1.38

0.78

0.0190

map04218

Cellular senescence

3 of 198

1.39

0.78

0.0190

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 63

2.11

3.02

5.36e-07

MAP-8943724

Regulation of PTEN gene transcription

5 of 71

2.06

2.97

5.36e-07

MAP-6804758

Regulation of TP53 Activity through Acetylation

4 of 40

2.21

2.74

3.58e-06

MAP-3214815

HDACs deacetylate histones

4 of 41

2.2

2.73

3.58e-06

MAP-4641265

Repression of WNT target genes

3 of 13

2.57

2.54

1.84e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001688

Cochlear ganglion

2 of 3

3.03

1.2

0.0069

BTO:0003667

Inner hair cell

2 of 6

2.73

1.19

0.0069

BTO:0004725

Embryonic fibroblast

3 of 142

1.53

0.76

0.0276

BTO:0000379

Embryo

5 of 1013

0.9

0.51

0.0345

BTO:0000174

Embryonic structure

6 of 1491

0.81

0.49

0.0276

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035098

ESC/E(Z) complex

4 of 11

2.77

3.6

2.07e-07

GOCC:0098831

Presynaptic active zone cytoplasmic component

3 of 15

2.51

2.23

6.89e-05

GOCC:0098681

Synaptic ribbon

2 of 3

3.03

1.67

0.00096

GOCC:0098684

Photoreceptor ribbon synapse

2 of 10

2.51

1.27

0.0046

GOCC:0090545

CHD-type complex

2 of 11

2.47

1.26

0.0048

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12265

Histone-binding protein RBBP4 or subunit C of CAF1 complex

3 of 3

3.21

2.83

7.69e-06

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 4

3.08

2.82

7.69e-06

PF08504

Runx inhibition domain

2 of 3

3.03

1.44

0.0025

PF00853

Runt domain

2 of 3

3.03

1.44

0.0025

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