DUSP19 protein (Taeniopygia guttata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

DUSP19

Uncharacterized protein. (283 aa)

Predicted Functional Partners:

NOL9

0.668

PAQR3

0.661

TBCCD1

0.485

SHPK

0.476

ENSTGUP00000019325

0.476

ENSTGUP00000031367

0.476

FKBP9

0.439

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP19	ENSTGUP00000019325	ENSTGUP00000011645	ENSTGUP00000019325	Uncharacterized protein.	Uncharacterized protein LOC115492334.	0.476
DUSP19	ENSTGUP00000031367	ENSTGUP00000011645	ENSTGUP00000031367	Uncharacterized protein.	annotation not available	0.476
DUSP19	FKBP9	ENSTGUP00000011645	ENSTGUP00000038295	Uncharacterized protein.	Peptidylprolyl isomerase.	0.439
DUSP19	NOL9	ENSTGUP00000011645	ENSTGUP00000020341	Uncharacterized protein.	Nucleolar protein 9.	0.668
DUSP19	PAQR3	ENSTGUP00000011645	ENSTGUP00000001566	Uncharacterized protein.	Progestin and adipoQ receptor family member 3.	0.661
DUSP19	SHPK	ENSTGUP00000011645	ENSTGUP00000007148	Uncharacterized protein.	Uncharacterized protein.	0.476
DUSP19	TBCCD1	ENSTGUP00000011645	ENSTGUP00000007004	Uncharacterized protein.	TBCC domain containing 1.	0.485
ENSTGUP00000019325	DUSP19	ENSTGUP00000019325	ENSTGUP00000011645	Uncharacterized protein LOC115492334.	Uncharacterized protein.	0.476
ENSTGUP00000031367	DUSP19	ENSTGUP00000031367	ENSTGUP00000011645	annotation not available	Uncharacterized protein.	0.476
FKBP9	DUSP19	ENSTGUP00000038295	ENSTGUP00000011645	Peptidylprolyl isomerase.	Uncharacterized protein.	0.439
NOL9	DUSP19	ENSTGUP00000020341	ENSTGUP00000011645	Nucleolar protein 9.	Uncharacterized protein.	0.668
NOL9	TBCCD1	ENSTGUP00000020341	ENSTGUP00000007004	Nucleolar protein 9.	TBCC domain containing 1.	0.439
PAQR3	DUSP19	ENSTGUP00000001566	ENSTGUP00000011645	Progestin and adipoQ receptor family member 3.	Uncharacterized protein.	0.661
SHPK	DUSP19	ENSTGUP00000007148	ENSTGUP00000011645	Uncharacterized protein.	Uncharacterized protein.	0.476
TBCCD1	DUSP19	ENSTGUP00000007004	ENSTGUP00000011645	TBCC domain containing 1.	Uncharacterized protein.	0.485
TBCCD1	NOL9	ENSTGUP00000007004	ENSTGUP00000020341	TBCC domain containing 1.	Nucleolar protein 9.	0.439

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044211

CTP salvage

2 of 3

2.6

1.31

0.0041

GO:0044206

UMP salvage

2 of 4

2.47

1.23

0.0055

GO:1901566

Organonitrogen compound biosynthetic process

9 of 611

0.94

0.93

3.83e-05

GO:0044271

Cellular nitrogen compound biosynthetic process

8 of 517

0.96

0.9

0.00015

GO:0006099

Tricarboxylic acid cycle

2 of 22

1.73

0.85

0.0207

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004849

Uridine kinase activity

2 of 3

2.6

1.04

0.0129

GO:0004834

Tryptophan synthase activity

2 of 2

2.77

1.04

0.0129

GO:0003735

Structural constituent of ribosome

3 of 58

1.49

0.76

0.0252

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

3 of 66

1.43

0.86

0.0128

GO:0005622

Intracellular anatomical structure

10 of 1962

0.48

0.36

0.0071

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33062286

(2020) Selection markers for transformation of the sequenced reference monokaryon Okayama 7#130 and homokaryon AmutBmut of Coprinopsis cinerea.

2 of 6

2.3

1.32

0.0034

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1147

Mixed, incl. CTP salvage, and Histone deacetylase domain

3 of 6

2.47

1.82

0.00042

CL:1996

Tryptophan biosynthesis

2 of 6

2.3

0.72

0.0473

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00260

Glycine, serine and threonine metabolism

4 of 79

1.48

1.25

0.0011

map03010

Ribosome

3 of 64

1.44

0.88

0.0114

map00620

Pyruvate metabolism

3 of 89

1.3

0.75

0.0195

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

2 of 34

1.54

0.67

0.0448

map01200

Carbon metabolism

3 of 150

1.07

0.55

0.0448

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

2 of 6

2.3

0.98

0.0156

KW-0689

Ribosomal protein

3 of 75

1.38

0.72

0.0273

KW-0028

Amino-acid biosynthesis

3 of 76

1.37

0.72

0.0273

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