STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1925 aa)    
Predicted Functional Partners:
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
   
 0.987
AGO1
Eukaryotic translation initiation factor 2C.
   
 0.933
AGO3
Argonaute RISC catalytic component 3; Belongs to the argonaute family.
   
 0.933
AGO4
Argonaute RISC component 4; Belongs to the argonaute family.
   
 0.933
TARBP2
TARBP2 subunit of RISC loading complex.
    
 0.928
DGCR8
DGCR8 microprocessor complex subunit.
   
 0.920
ENSTGUP00000020667
annotation not available
    
 0.902
ENSTGUP00000024832
annotation not available
    
 0.902
ENSTGUP00000036769
annotation not available
    
 0.902
STAU1
Staufen double-stranded RNA binding protein 1.
    
 0.847
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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