JAG2 protein (Taeniopygia guttata) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

JAG2

Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1326 aa)

Predicted Functional Partners:

NOTCH1

0.995

NOTCH2

0.962

JAG1

0.955

RBPJ

0.692

H0ZRA3_TAEGU

0.667

ENSTGUP00000013137

0.645

ENSTGUP00000032818

0.579

DLL4

0.565

SUPT6H

0.551

ENSTGUP00000025929

0.504

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	ENSTGUP00000013137	ENSTGUP00000011110	ENSTGUP00000013137	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.622
DLL4	ENSTGUP00000032818	ENSTGUP00000011110	ENSTGUP00000032818	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Muscle M-line assembly protein unc-89-like.	0.579
DLL4	H0ZRA3_TAEGU	ENSTGUP00000011110	ENSTGUP00000036419	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.643
DLL4	JAG1	ENSTGUP00000011110	ENSTGUP00000006280	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.462
DLL4	JAG2	ENSTGUP00000011110	ENSTGUP00000013307	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.565
DLL4	NOTCH1	ENSTGUP00000011110	ENSTGUP00000006342	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.997
DLL4	NOTCH2	ENSTGUP00000011110	ENSTGUP00000031333	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.960
DLL4	RBPJ	ENSTGUP00000011110	ENSTGUP00000036782	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.697
ENSTGUP00000013137	DLL4	ENSTGUP00000013137	ENSTGUP00000011110	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.622
ENSTGUP00000013137	ENSTGUP00000032818	ENSTGUP00000013137	ENSTGUP00000032818	annotation not available	Muscle M-line assembly protein unc-89-like.	0.579
ENSTGUP00000013137	H0ZRA3_TAEGU	ENSTGUP00000013137	ENSTGUP00000036419	annotation not available	Uncharacterized protein.	0.898
ENSTGUP00000013137	JAG1	ENSTGUP00000013137	ENSTGUP00000006280	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.685
ENSTGUP00000013137	JAG2	ENSTGUP00000013137	ENSTGUP00000013307	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.645
ENSTGUP00000013137	RBPJ	ENSTGUP00000013137	ENSTGUP00000036782	annotation not available	Recombination signal binding protein for immunoglobulin kappa J region.	0.854
ENSTGUP00000025929	JAG1	ENSTGUP00000025929	ENSTGUP00000006280	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.548
ENSTGUP00000025929	JAG2	ENSTGUP00000025929	ENSTGUP00000013307	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.504
ENSTGUP00000025929	NOTCH1	ENSTGUP00000025929	ENSTGUP00000006342	annotation not available	Notch receptor 1.	0.585
ENSTGUP00000032818	DLL4	ENSTGUP00000032818	ENSTGUP00000011110	Muscle M-line assembly protein unc-89-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.579
ENSTGUP00000032818	ENSTGUP00000013137	ENSTGUP00000032818	ENSTGUP00000013137	Muscle M-line assembly protein unc-89-like.	annotation not available	0.579
ENSTGUP00000032818	H0ZRA3_TAEGU	ENSTGUP00000032818	ENSTGUP00000036419	Muscle M-line assembly protein unc-89-like.	Uncharacterized protein.	0.579

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.862

expected number of edges:

19

PPI enrichment p-value:

0.537

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

5 of 39

2.4

3.79

3.56e-08

GO:0006518

Peptide metabolic process

9 of 433

1.61

3.01

2.69e-10

GO:0006572

Tyrosine catabolic process

3 of 6

2.99

2.72

1.13e-05

GO:0006559

L-phenylalanine catabolic process

3 of 9

2.81

2.51

2.54e-05

GO:0006412

Translation

5 of 333

1.47

1.46

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004364

Glutathione transferase activity

4 of 16

2.69

3.38

4.76e-07

GO:0003746

Translation elongation factor activity

4 of 24

2.51

3.16

1.00e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005853

Eukaryotic translation elongation factor 1 complex

2 of 2

3.29

1.52

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3977

Eukaryotic Translation Elongation, and Translation release factor complex

4 of 6

3.11

4.07

3.70e-08

CL:1155

Tyrosine catabolism, and 4-hydroxyphenylpyruvate dioxygenase

3 of 5

3.07

2.69

1.32e-05

CL:2389

Glutathione S-transferase, C-terminal domain, and Epoxide metabolic process

3 of 10

2.77

2.37

4.49e-05

CL:2393

Glutathione S-transferase, N-terminal domain

2 of 5

2.89

1.61

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru00982

Drug metabolism - cytochrome P450

3 of 35

2.22

2.0

0.00014

tru00980

Metabolism of xenobiotics by cytochrome P450

3 of 36

2.21

2.0

0.00014

tru00983

Drug metabolism - other enzymes

3 of 57

2.01

1.87

0.00018

tru00480

Glutathione metabolism

3 of 56

2.02

1.87

0.00018

tru01100

Metabolic pathways

5 of 1393

0.84

0.56

0.0130

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156842

Eukaryotic Translation Elongation

4 of 7

3.05

4.19

2.06e-08

MAP-156590

Glutathione conjugation

4 of 27

2.46

3.14

9.79e-07

MAP-8963684

Tyrosine catabolism

3 of 6

2.99

2.92

4.68e-06

MAP-8963691

Phenylalanine and tyrosine metabolism

3 of 18

2.51

2.33

4.43e-05

MAP-156580

Phase II - Conjugation of compounds

4 of 76

2.01

2.24

2.43e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005853

Eukaryotic translation elongation factor 1 complex

3 of 3

3.29

3.05

3.05e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0251

Elongation factor

4 of 11

2.85

4.18

1.71e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14497

Glutathione S-transferase, C-terminal domain

5 of 9

3.03

5.55

5.70e-11

PF02798

Glutathione S-transferase, N-terminal domain

4 of 9

2.94

4.07

3.11e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

6 of 28

2.62

5.44

2.82e-11

IPR004046

Glutathione S-transferase, C-terminal

4 of 12

2.81

3.61

2.09e-07

IPR004045

Glutathione S-transferase, N-terminal

4 of 15

2.71

3.5

2.96e-07

IPR010987

Glutathione S-transferase, C-terminal-like

4 of 20

2.59

3.3

6.08e-07

IPR036219

Translation elongation factor eEF-1beta-like superfamily

3 of 4

3.16

2.96

4.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01182

Eukaryotic elongation factor 1 beta central acidic region

3 of 4

3.16

3.07

2.74e-06

SM00888

EF-1 guanine nucleotide exchange domain

3 of 4

3.16

3.07

2.74e-06

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