HSPB11 protein (Taeniopygia guttata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

HSPB11

Heat shock protein family B (small) member 11. (141 aa)

Predicted Functional Partners:

ANAPC5

0.967

CDC27

0.964

ANAPC1

0.964

ANAPC4

0.964

CDC16

0.964

FAM89A

0.964

IFT27

0.958

ANAPC7

0.953

IFT22

0.951

IFT46

0.929

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC1	ANAPC4	ENSTGUP00000007633	ENSTGUP00000016892	Anaphase promoting complex subunit 1.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.999
ANAPC1	ANAPC5	ENSTGUP00000007633	ENSTGUP00000006151	Anaphase promoting complex subunit 1.	ANAPC5 domain-containing protein.	0.999
ANAPC1	ANAPC7	ENSTGUP00000007633	ENSTGUP00000005881	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 7.	0.999
ANAPC1	CDC16	ENSTGUP00000007633	ENSTGUP00000024086	Anaphase promoting complex subunit 1.	Cell division cycle 16.	0.999
ANAPC1	CDC27	ENSTGUP00000007633	ENSTGUP00000001977	Anaphase promoting complex subunit 1.	Cell division cycle 27.	0.999
ANAPC1	FAM89A	ENSTGUP00000007633	ENSTGUP00000034934	Anaphase promoting complex subunit 1.	Family with sequence similarity 89 member A.	0.998
ANAPC1	HSPB11	ENSTGUP00000007633	ENSTGUP00000021040	Anaphase promoting complex subunit 1.	Heat shock protein family B (small) member 11.	0.964
ANAPC4	ANAPC1	ENSTGUP00000016892	ENSTGUP00000007633	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Anaphase promoting complex subunit 1.	0.999
ANAPC4	ANAPC5	ENSTGUP00000016892	ENSTGUP00000006151	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	ANAPC5 domain-containing protein.	0.999
ANAPC4	ANAPC7	ENSTGUP00000016892	ENSTGUP00000005881	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Anaphase promoting complex subunit 7.	0.999
ANAPC4	CDC16	ENSTGUP00000016892	ENSTGUP00000024086	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Cell division cycle 16.	0.999
ANAPC4	CDC27	ENSTGUP00000016892	ENSTGUP00000001977	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Cell division cycle 27.	0.999
ANAPC4	FAM89A	ENSTGUP00000016892	ENSTGUP00000034934	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Family with sequence similarity 89 member A.	0.998
ANAPC4	HSPB11	ENSTGUP00000016892	ENSTGUP00000021040	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Heat shock protein family B (small) member 11.	0.964
ANAPC5	ANAPC1	ENSTGUP00000006151	ENSTGUP00000007633	ANAPC5 domain-containing protein.	Anaphase promoting complex subunit 1.	0.999
ANAPC5	ANAPC4	ENSTGUP00000006151	ENSTGUP00000016892	ANAPC5 domain-containing protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.999
ANAPC5	ANAPC7	ENSTGUP00000006151	ENSTGUP00000005881	ANAPC5 domain-containing protein.	Anaphase promoting complex subunit 7.	0.999
ANAPC5	CDC16	ENSTGUP00000006151	ENSTGUP00000024086	ANAPC5 domain-containing protein.	Cell division cycle 16.	0.999
ANAPC5	CDC27	ENSTGUP00000006151	ENSTGUP00000001977	ANAPC5 domain-containing protein.	Cell division cycle 27.	0.999
ANAPC5	FAM89A	ENSTGUP00000006151	ENSTGUP00000034934	ANAPC5 domain-containing protein.	Family with sequence similarity 89 member A.	0.998

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.871

expected number of edges:

12

PPI enrichment p-value:

0.0535

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005986

Sucrose biosynthetic process

2 of 2

3.28

1.07

0.0121

GO:0006002

Fructose 6-phosphate metabolic process

2 of 9

2.62

1.05

0.0125

GO:0030388

Fructose 1,6-bisphosphate metabolic process

2 of 11

2.54

1.04

0.0125

GO:0006000

Fructose metabolic process

2 of 11

2.54

1.04

0.0125

GO:0036158

Outer dynein arm assembly

2 of 14

2.43

1.02

0.0134

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047617

acyl-CoA hydrolase activity

3 of 24

2.37

1.65

0.00084

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.28

1.6

0.0013

GO:0004784

Superoxide dismutase activity

2 of 3

3.1

1.58

0.0014

GO:0045504

Dynein heavy chain binding

2 of 15

2.4

1.03

0.0129

GO:0005507

Copper ion binding

2 of 38

2.0

0.71

0.0468

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030286

Dynein complex

3 of 56

2.01

1.22

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3046

Dynein heavy chain binding, and Dynein light chain type 1

3 of 5

3.05

2.52

2.69e-05

CL:34035

Acyl-CoA thioesterase, long chain, and Thioesterase domain

3 of 7

2.91

2.49

2.88e-05

CL:24468

Superoxide dismutase activity, and Regulation of oxidative phosphorylation uncoupler activity

2 of 5

2.88

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00062

Fatty acid elongation

3 of 51

2.05

1.67

0.00052

map01040

Biosynthesis of unsaturated fatty acids

3 of 63

1.95

1.64

0.00052

map00051

Fructose and mannose metabolism

2 of 63

1.78

0.82

0.0258

map00030

Pentose phosphate pathway

2 of 55

1.84

0.82

0.0258

map00010

Glycolysis / Gluconeogenesis

2 of 99

1.58

0.66

0.0484

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036157

Outer dynein arm

2 of 4

2.98

1.33

0.0040

GOCC:0030286

Dynein complex

3 of 51

2.05

1.25

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0186

Copper

2 of 9

2.62

1.28

0.0046

KW-0119

Carbohydrate metabolism

2 of 33

2.06

0.86

0.0246

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.28

1.38

0.0033

PF00080

Copper/zinc superoxide dismutase (SODC)

2 of 3

3.1

1.38

0.0033

PF08840

BAAT / Acyl-CoA thioester hydrolase C terminal

2 of 4

2.98

1.37

0.0033

PF04775

Acyl-CoA thioester hydrolase/BAAT N-terminal region

2 of 8

2.67

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.28

1.1

0.0106

IPR036423

Superoxide dismutase-like, copper/zinc binding domain superfamily

2 of 3

3.1

1.1

0.0106

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.28

1.1

0.0106

IPR028343

Fructose-1,6-bisphosphatase

2 of 2

3.28

1.1

0.0106

IPR024134

Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone

2 of 3

3.1

1.1

0.0106

(more ...)

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