STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KMT5CLysine methyltransferase 5C. (486 aa)    
Predicted Functional Partners:
LOC100221944
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.605
LOC100221944-2
Uncharacterized LOC100221944.
   
 0.605
LOC100221944-3
Uncharacterized LOC100221944.
   
 0.605
TRIP12
Thyroid hormone receptor interactor 12.
   
  
 0.600
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
  
 0.521
KMT5A
SET domain-containing protein.
      
 0.493
CCT7
T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
      
 0.489
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
      
 0.422
ASH1L
ASH1 like histone lysine methyltransferase.
   
  
 0.422
TP53BP1
Tumor protein p53 binding protein 1.
    
 
 0.413
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.