PECR protein (Taeniopygia guttata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PECR

Uncharacterized protein. (284 aa)

Predicted Functional Partners:

ACAA1

0.765

ACOX2

0.742

EHHADH

0.719

PEX5

0.669

PEX7

0.637

AMACR

0.609

SCP2

0.565

HSD17B12

0.564

PEX12

0.547

RPS27A

0.541

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACOX2	ENSTGUP00000035851	ENSTGUP00000009531	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.838
ACAA1	AMACR	ENSTGUP00000035851	ENSTGUP00000002006	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Alpha-methylacyl-CoA racemase.	0.640
ACAA1	EHHADH	ENSTGUP00000035851	ENSTGUP00000007186	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.985
ACAA1	HSD17B12	ENSTGUP00000035851	ENSTGUP00000026424	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.507
ACAA1	PECR	ENSTGUP00000035851	ENSTGUP00000031665	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.765
ACAA1	PEX12	ENSTGUP00000035851	ENSTGUP00000004983	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.762
ACAA1	PEX5	ENSTGUP00000035851	ENSTGUP00000029536	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 5.	0.804
ACAA1	PEX7	ENSTGUP00000035851	ENSTGUP00000028495	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 7.	0.994
ACAA1	RPS27A	ENSTGUP00000035851	ENSTGUP00000007289	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Ubiquitin-like domain-containing protein.	0.622
ACAA1	SCP2	ENSTGUP00000035851	ENSTGUP00000009411	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.979
ACOX2	ACAA1	ENSTGUP00000009531	ENSTGUP00000035851	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.838
ACOX2	AMACR	ENSTGUP00000009531	ENSTGUP00000002006	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Alpha-methylacyl-CoA racemase.	0.962
ACOX2	EHHADH	ENSTGUP00000009531	ENSTGUP00000007186	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.850
ACOX2	HSD17B12	ENSTGUP00000009531	ENSTGUP00000026424	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.501
ACOX2	PECR	ENSTGUP00000009531	ENSTGUP00000031665	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Uncharacterized protein.	0.742
ACOX2	PEX12	ENSTGUP00000009531	ENSTGUP00000004983	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.731
ACOX2	PEX5	ENSTGUP00000009531	ENSTGUP00000029536	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisomal biogenesis factor 5.	0.876
ACOX2	PEX7	ENSTGUP00000009531	ENSTGUP00000028495	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisomal biogenesis factor 7.	0.517
ACOX2	RPS27A	ENSTGUP00000009531	ENSTGUP00000007289	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Ubiquitin-like domain-containing protein.	0.573
ACOX2	SCP2	ENSTGUP00000009531	ENSTGUP00000009411	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.906

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.706

expected number of edges:

14

PPI enrichment p-value:

3.36e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

8 of 114

1.41

2.12

5.02e-08

GO:0010467

Gene expression

10 of 236

1.19

1.68

7.21e-09

GO:0009059

Macromolecule biosynthetic process

9 of 243

1.14

1.45

1.21e-07

GO:0044271

Cellular nitrogen compound biosynthetic process

9 of 362

0.96

1.04

2.60e-06

GO:0034641

Cellular nitrogen compound metabolic process

10 of 700

0.72

0.66

2.91e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 61

1.63

2.59

5.54e-08

GO:0019843

rRNA binding

5 of 43

1.63

1.94

1.80e-05

GO:0003676

Nucleic acid binding

7 of 572

0.65

0.4

0.0298

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

8 of 65

1.66

3.21

1.54e-10

GO:0015934

Large ribosomal subunit

3 of 9

2.09

2.08

7.14e-05

GO:0032991

Protein-containing complex

4 of 176

0.92

0.61

0.0128

GO:0005622

Intracellular anatomical structure

11 of 1309

0.49

0.43

7.81e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:106

Ribosome, and Translational elongation

10 of 79

1.67

3.81

7.68e-14

CL:90

Translation, and Transcription, DNA-templated

11 of 128

1.5

3.13

4.73e-14

CL:118

Ribosome

7 of 57

1.66

2.9

4.61e-09

CL:119

Structural constituent of ribosome

6 of 52

1.63

2.48

1.78e-07

CL:164

rRNA-binding, and Elongation factor Tu domain 2

4 of 19

1.89

2.25

1.39e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

8 of 65

1.66

3.21

1.54e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

5 of 46

1.6

1.83

3.34e-05

GOCC:0044391

Ribosomal subunit

3 of 17

1.81

1.42

0.0012

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 7

2.02

1.1

0.0079

GOCC:0043229

Intracellular organelle

8 of 400

0.87

0.78

0.00018

GOCC:0005622

Intracellular

11 of 1532

0.42

0.35

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

8 of 70

1.62

3.03

3.98e-10

KW-0699

rRNA-binding

5 of 40

1.66

2.18

3.85e-06

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