CBLN4 protein (Taeniopygia guttata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CBLN4

Cerebellin 4 precursor. (193 aa)

Predicted Functional Partners:

MC3R

0.575

MAOA

0.448

FHDC1

0.430

DAAM2

0.406

FMNL2

0.406

FMN2

0.405

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBLN4	DAAM2	ENSTGUP00000035377	ENSTGUP00000025966	Cerebellin 4 precursor.	Dishevelled associated activator of morphogenesis 2.	0.406
CBLN4	FHDC1	ENSTGUP00000035377	ENSTGUP00000005221	Cerebellin 4 precursor.	FH2 domain containing 1.	0.430
CBLN4	FMN2	ENSTGUP00000035377	ENSTGUP00000018915	Cerebellin 4 precursor.	FH2 domain-containing protein.	0.405
CBLN4	FMNL2	ENSTGUP00000035377	ENSTGUP00000030861	Cerebellin 4 precursor.	Formin like 2.	0.406
CBLN4	MAOA	ENSTGUP00000035377	ENSTGUP00000006538	Cerebellin 4 precursor.	Amine oxidase.	0.448
CBLN4	MC3R	ENSTGUP00000035377	ENSTGUP00000008719	Cerebellin 4 precursor.	Melanocortin 3 receptor.	0.575
DAAM2	CBLN4	ENSTGUP00000025966	ENSTGUP00000035377	Dishevelled associated activator of morphogenesis 2.	Cerebellin 4 precursor.	0.406
DAAM2	FMNL2	ENSTGUP00000025966	ENSTGUP00000030861	Dishevelled associated activator of morphogenesis 2.	Formin like 2.	0.522
FHDC1	CBLN4	ENSTGUP00000005221	ENSTGUP00000035377	FH2 domain containing 1.	Cerebellin 4 precursor.	0.430
FHDC1	FMN2	ENSTGUP00000005221	ENSTGUP00000018915	FH2 domain containing 1.	FH2 domain-containing protein.	0.428
FHDC1	FMNL2	ENSTGUP00000005221	ENSTGUP00000030861	FH2 domain containing 1.	Formin like 2.	0.524
FMN2	CBLN4	ENSTGUP00000018915	ENSTGUP00000035377	FH2 domain-containing protein.	Cerebellin 4 precursor.	0.405
FMN2	FHDC1	ENSTGUP00000018915	ENSTGUP00000005221	FH2 domain-containing protein.	FH2 domain containing 1.	0.428
FMN2	FMNL2	ENSTGUP00000018915	ENSTGUP00000030861	FH2 domain-containing protein.	Formin like 2.	0.408
FMNL2	CBLN4	ENSTGUP00000030861	ENSTGUP00000035377	Formin like 2.	Cerebellin 4 precursor.	0.406
FMNL2	DAAM2	ENSTGUP00000030861	ENSTGUP00000025966	Formin like 2.	Dishevelled associated activator of morphogenesis 2.	0.522
FMNL2	FHDC1	ENSTGUP00000030861	ENSTGUP00000005221	Formin like 2.	FH2 domain containing 1.	0.524
FMNL2	FMN2	ENSTGUP00000030861	ENSTGUP00000018915	Formin like 2.	FH2 domain-containing protein.	0.408
MAOA	CBLN4	ENSTGUP00000006538	ENSTGUP00000035377	Amine oxidase.	Cerebellin 4 precursor.	0.448
MC3R	CBLN4	ENSTGUP00000008719	ENSTGUP00000035377	Melanocortin 3 receptor.	Cerebellin 4 precursor.	0.575

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

11 of 238

2.06

6.78

2.42e-19

GO:1903241

U2-type prespliceosome assembly

2 of 3

3.22

1.81

0.00055

GO:0000245

Spliceosomal complex assembly

3 of 46

2.21

1.8

0.00035

GO:0022618

Ribonucleoprotein complex assembly

4 of 162

1.79

1.72

0.00020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

3 of 3

3.39

3.25

1.35e-06

GO:0003723

RNA binding

10 of 1350

1.26

1.89

2.67e-09

GO:0030620

U2 snRNA binding

2 of 7

2.85

1.44

0.0025

GO:0003676

Nucleic acid binding

11 of 4200

0.81

0.83

1.35e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071011

Precatalytic spliceosome

11 of 51

2.73

12.67

4.16e-27

GO:0005686

U2 snRNP

9 of 18

3.09

12.32

3.56e-24

GO:0071005

U2-type precatalytic spliceosome

10 of 46

2.73

11.51

2.64e-24

GO:0097525

Spliceosomal snRNP complex

10 of 54

2.66

11.1

6.75e-24

GO:0005684

U2-type spliceosomal complex

11 of 90

2.48

10.7

6.50e-25

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

U2 snRNP

10 of 12

3.32

14.56

6.18e-28

CL:26586

Spliceosomal snRNP complex, and Nuclear cap binding complex

11 of 37

2.87

13.55

6.18e-28

CL:26590

Splicing factor binding, and PSP, proline-rich

6 of 6

3.39

8.48

3.13e-16

CL:26601

U2-type prespliceosome assembly, and U2 small nuclear ribonucleoprotein A

4 of 6

3.22

4.9

1.17e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

11 of 279

1.99

6.58

3.21e-20

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

7 of 57

2.48

6.49

5.09e-14

MAP-72172

mRNA Splicing

11 of 303

1.95

6.1

6.60e-19

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 407

1.83

5.2

8.02e-18

MAP-8953854

Metabolism of RNA

11 of 993

1.44

2.86

6.66e-14

MAP-72163

mRNA Splicing - Major Pathway

4 of 281

1.55

1.28

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

11 of 470

1.76

4.71

7.19e-17

GOCC:0097525

Spliceosomal snRNP complex

5 of 38

2.51

4.4

2.76e-09

GOCC:0005686

U2 snRNP

3 of 5

3.17

3.42

6.13e-07

GOCC:0005681

Spliceosomal complex

5 of 117

2.03

3.1

1.95e-07

GOCC:0005689

U12-type spliceosomal complex

2 of 9

2.74

1.6

0.0012

(more ...)

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