node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIN80202.1 | SIO29204.1 | SAMN05421769_0100 | SAMN05421769_3240 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | DNA topoisomerase-1. | 0.487 |
SIN80202.1 | polA | SAMN05421769_0100 | SAMN05421769_1539 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
SIN80202.1 | rnhA | SAMN05421769_0100 | SAMN05421769_2748 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.493 |
SIN80202.1 | rnhB | SAMN05421769_0100 | SAMN05421769_4142 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.940 |
SIN80202.1 | thyA | SAMN05421769_0100 | SAMN05421769_1750 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.762 |
SIO25738.1 | SIO25751.1 | SAMN05421769_3080 | SAMN05421769_3081 | NADH dehydrogenase subunit E. | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.999 |
SIO25738.1 | SIO25770.1 | SAMN05421769_3080 | SAMN05421769_3083 | NADH dehydrogenase subunit E. | NADH dehydrogenase subunit G. | 0.999 |
SIO25738.1 | SIO34489.1 | SAMN05421769_3080 | SAMN05421769_3726 | NADH dehydrogenase subunit E. | Rieske [2Fe-2S] domain-containing protein. | 0.975 |
SIO25738.1 | rnhB | SAMN05421769_3080 | SAMN05421769_4142 | NADH dehydrogenase subunit E. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.723 |
SIO25751.1 | SIO25738.1 | SAMN05421769_3081 | SAMN05421769_3080 | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | NADH dehydrogenase subunit E. | 0.999 |
SIO25751.1 | SIO25770.1 | SAMN05421769_3081 | SAMN05421769_3083 | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | NADH dehydrogenase subunit G. | 0.999 |
SIO25751.1 | SIO34489.1 | SAMN05421769_3081 | SAMN05421769_3726 | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | Rieske [2Fe-2S] domain-containing protein. | 0.974 |
SIO25751.1 | rnhB | SAMN05421769_3081 | SAMN05421769_4142 | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.723 |
SIO25770.1 | SIO25738.1 | SAMN05421769_3083 | SAMN05421769_3080 | NADH dehydrogenase subunit G. | NADH dehydrogenase subunit E. | 0.999 |
SIO25770.1 | SIO25751.1 | SAMN05421769_3083 | SAMN05421769_3081 | NADH dehydrogenase subunit G. | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.999 |
SIO25770.1 | SIO34489.1 | SAMN05421769_3083 | SAMN05421769_3726 | NADH dehydrogenase subunit G. | Rieske [2Fe-2S] domain-containing protein. | 0.973 |
SIO25770.1 | rnhB | SAMN05421769_3083 | SAMN05421769_4142 | NADH dehydrogenase subunit G. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.733 |
SIO29204.1 | SIN80202.1 | SAMN05421769_3240 | SAMN05421769_0100 | DNA topoisomerase-1. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.487 |
SIO29204.1 | polA | SAMN05421769_3240 | SAMN05421769_1539 | DNA topoisomerase-1. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.499 |
SIO29204.1 | rnhB | SAMN05421769_3240 | SAMN05421769_4142 | DNA topoisomerase-1. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.828 |