K5X9L2_AGABU protein (Agaricus bisporus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

K5X9L2_AGABU

Uncharacterized protein. (1222 aa)

Predicted Functional Partners:

K5VU70_AGABU

0.954

K5W281_AGABU

0.771

K5XBB4_AGABU

0.630

K5WAS4_AGABU

0.575

K5XPT8_AGABU

0.479

K5VXF3_AGABU

0.454

K5XFG0_AGABU

0.422

K5VYI1_AGABU

0.411

K5XZ54_AGABU

0.407

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VU70_AGABU	K5W281_AGABU	K5VU70	K5W281	Uncharacterized protein.	Uncharacterized protein.	0.864
K5VU70_AGABU	K5X9L2_AGABU	K5VU70	K5X9L2	Uncharacterized protein.	Uncharacterized protein.	0.954
K5VXF3_AGABU	K5VYI1_AGABU	K5VXF3	K5VYI1	Uncharacterized protein.	PAS domain-containing protein.	0.869
K5VXF3_AGABU	K5X9L2_AGABU	K5VXF3	K5X9L2	Uncharacterized protein.	Uncharacterized protein.	0.454
K5VYI1_AGABU	K5VXF3_AGABU	K5VYI1	K5VXF3	PAS domain-containing protein.	Uncharacterized protein.	0.869
K5VYI1_AGABU	K5X9L2_AGABU	K5VYI1	K5X9L2	PAS domain-containing protein.	Uncharacterized protein.	0.411
K5W281_AGABU	K5VU70_AGABU	K5W281	K5VU70	Uncharacterized protein.	Uncharacterized protein.	0.864
K5W281_AGABU	K5X9L2_AGABU	K5W281	K5X9L2	Uncharacterized protein.	Uncharacterized protein.	0.771
K5WAS4_AGABU	K5X9L2_AGABU	K5WAS4	K5X9L2	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.575
K5WAS4_AGABU	K5XBB4_AGABU	K5WAS4	K5XBB4	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.643
K5WAS4_AGABU	K5XPT8_AGABU	K5WAS4	K5XPT8	WD_REPEATS_REGION domain-containing protein.	Phosphodiesterase.	0.669
K5X9L2_AGABU	K5VU70_AGABU	K5X9L2	K5VU70	Uncharacterized protein.	Uncharacterized protein.	0.954
K5X9L2_AGABU	K5VXF3_AGABU	K5X9L2	K5VXF3	Uncharacterized protein.	Uncharacterized protein.	0.454
K5X9L2_AGABU	K5VYI1_AGABU	K5X9L2	K5VYI1	Uncharacterized protein.	PAS domain-containing protein.	0.411
K5X9L2_AGABU	K5W281_AGABU	K5X9L2	K5W281	Uncharacterized protein.	Uncharacterized protein.	0.771
K5X9L2_AGABU	K5WAS4_AGABU	K5X9L2	K5WAS4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.575
K5X9L2_AGABU	K5XBB4_AGABU	K5X9L2	K5XBB4	Uncharacterized protein.	Uncharacterized protein.	0.630
K5X9L2_AGABU	K5XFG0_AGABU	K5X9L2	K5XFG0	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.422
K5X9L2_AGABU	K5XPT8_AGABU	K5X9L2	K5XPT8	Uncharacterized protein.	Phosphodiesterase.	0.479
K5X9L2_AGABU	K5XZ54_AGABU	K5X9L2	K5XZ54	Uncharacterized protein.	CASP_C domain-containing protein.	0.407

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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