STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
K5XA77_AGABUHistone domain-containing protein. (111 aa)    
Predicted Functional Partners:
K5X277_AGABU
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.923
K5W749_AGABU
Histone H2B; Belongs to the histone H2B family.
 
 
 0.921
K5WPY6_AGABU
Histone H2B; Belongs to the histone H2B family.
 
 
 0.919
K5X2V4_AGABU
Uncharacterized protein.
    
 0.892
K5XPF5_AGABU
Histone H2A; Belongs to the histone H2A family.
 
 
 0.870
K5X8I2_AGABU
WD_REPEATS_REGION domain-containing protein.
   
 0.842
K5WUT8_AGABU
Uncharacterized protein.
    
 0.838
K5WI14_AGABU
Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
 
 
 0.835
K5X633_AGABU
Uncharacterized protein.
   
 0.833
K5XIP8_AGABU
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
   
 0.827
Your Current Organism:
Agaricus bisporus
NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.