K5XC24_AGABU protein (Agaricus bisporus) - STRING interaction network

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

K5XC24_AGABU

Uncharacterized protein. (1132 aa)

Predicted Functional Partners:

K5XKY9_AGABU

0.927

K5XWW5_AGABU

0.896

K5W906_AGABU

0.655

K5WP36_AGABU

0.614

K5X5W9_AGABU

0.571

K5WAL9_AGABU

0.531

K5W6M1_AGABU

0.487

K5XRZ2_AGABU

0.484

K5X8F9_AGABU

0.471

K5VQH0_AGABU

0.452

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VQH0_AGABU	K5W906_AGABU	K5VQH0	K5W906	Uncharacterized protein.	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.	0.459
K5VQH0_AGABU	K5X5W9_AGABU	K5VQH0	K5X5W9	Uncharacterized protein.	UDP-glucose 6-dehydrogenase.	0.488
K5VQH0_AGABU	K5XC24_AGABU	K5VQH0	K5XC24	Uncharacterized protein.	Uncharacterized protein.	0.452
K5VQH0_AGABU	K5XKY9_AGABU	K5VQH0	K5XKY9	Uncharacterized protein.	Uncharacterized protein.	0.650
K5W6M1_AGABU	K5XC24_AGABU	K5W6M1	K5XC24	Tryptophan synthase.	Uncharacterized protein.	0.487
K5W6M1_AGABU	K5XRZ2_AGABU	K5W6M1	K5XRZ2	Tryptophan synthase.	Acetolactate synthase.	0.744
K5W906_AGABU	K5VQH0_AGABU	K5W906	K5VQH0	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.	Uncharacterized protein.	0.459
K5W906_AGABU	K5X5W9_AGABU	K5W906	K5X5W9	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.	UDP-glucose 6-dehydrogenase.	0.537
K5W906_AGABU	K5XC24_AGABU	K5W906	K5XC24	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.	Uncharacterized protein.	0.655
K5WAL9_AGABU	K5WP36_AGABU	K5WAL9	K5WP36	Uncharacterized protein.	Uncharacterized protein.	0.467
K5WAL9_AGABU	K5XC24_AGABU	K5WAL9	K5XC24	Uncharacterized protein.	Uncharacterized protein.	0.531
K5WP36_AGABU	K5WAL9_AGABU	K5WP36	K5WAL9	Uncharacterized protein.	Uncharacterized protein.	0.467
K5WP36_AGABU	K5XC24_AGABU	K5WP36	K5XC24	Uncharacterized protein.	Uncharacterized protein.	0.614
K5X5W9_AGABU	K5VQH0_AGABU	K5X5W9	K5VQH0	UDP-glucose 6-dehydrogenase.	Uncharacterized protein.	0.488
K5X5W9_AGABU	K5W906_AGABU	K5X5W9	K5W906	UDP-glucose 6-dehydrogenase.	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.	0.537
K5X5W9_AGABU	K5XC24_AGABU	K5X5W9	K5XC24	UDP-glucose 6-dehydrogenase.	Uncharacterized protein.	0.571
K5X5W9_AGABU	K5XKY9_AGABU	K5X5W9	K5XKY9	UDP-glucose 6-dehydrogenase.	Uncharacterized protein.	0.624
K5X8F9_AGABU	K5XC24_AGABU	K5X8F9	K5XC24	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.471
K5XC24_AGABU	K5VQH0_AGABU	K5XC24	K5VQH0	Uncharacterized protein.	Uncharacterized protein.	0.452
K5XC24_AGABU	K5W6M1_AGABU	K5XC24	K5W6M1	Uncharacterized protein.	Tryptophan synthase.	0.487

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

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