STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (722 aa)    
Predicted Functional Partners:
K5XDN1_AGABU
AA_TRNA_LIGASE_II domain-containing protein.
   
 0.974
K5XSZ7_AGABU
DUF1767 domain-containing protein.
    
 0.854
K5WXT1_AGABU
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.843
K5WAC3_AGABU
AA_TRNA_LIGASE_II domain-containing protein.
   
 0.839
K5X4P0_AGABU
AA_TRNA_LIGASE_II domain-containing protein.
   
 0.839
K5VQK1_AGABU
Uncharacterized protein.
     
 0.821
K5Y7H7_AGABU
Uncharacterized protein.
   
 
 0.806
K5WZQ3_AGABU
Uncharacterized protein.
   
 0.803
K5XD31_AGABU
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
    
 
 0.799
K5XE41_AGABU
WAPL domain-containing protein.
    
 
 0.799
Your Current Organism:
Agaricus bisporus
NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8
Server load: low (16%) [HD]