K5XQB0_AGABU protein (Agaricus bisporus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

K5XQB0_AGABU

TIP120 domain-containing protein. (1219 aa)

Predicted Functional Partners:

K5W810_AGABU

0.965

K5VSQ0_AGABU

0.963

K5VY40_AGABU

0.915

K5X9W2_AGABU

0.915

K5VW89_AGABU

0.909

K5WPX3_AGABU

0.862

K5X9R9_AGABU

0.854

K5XVX6_AGABU

0.852

K5Y7C3_AGABU

0.807

K5Y4Y4_AGABU

0.800

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VSQ0_AGABU	K5VW89_AGABU	K5VSQ0	K5VW89	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.954
K5VSQ0_AGABU	K5VY40_AGABU	K5VSQ0	K5VY40	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.935
K5VSQ0_AGABU	K5W810_AGABU	K5VSQ0	K5W810	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.982
K5VSQ0_AGABU	K5WPX3_AGABU	K5VSQ0	K5WPX3	RING-type domain-containing protein.	Uncharacterized protein.	0.614
K5VSQ0_AGABU	K5X9R9_AGABU	K5VSQ0	K5X9R9	RING-type domain-containing protein.	Ubiquitin-like domain-containing protein.	0.984
K5VSQ0_AGABU	K5X9W2_AGABU	K5VSQ0	K5X9W2	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.935
K5VSQ0_AGABU	K5XQB0_AGABU	K5VSQ0	K5XQB0	RING-type domain-containing protein.	TIP120 domain-containing protein.	0.963
K5VSQ0_AGABU	K5XVX6_AGABU	K5VSQ0	K5XVX6	RING-type domain-containing protein.	CPSF_A domain-containing protein.	0.996
K5VSQ0_AGABU	K5Y4Y4_AGABU	K5VSQ0	K5Y4Y4	RING-type domain-containing protein.	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	0.952
K5VSQ0_AGABU	K5Y7C3_AGABU	K5VSQ0	K5Y7C3	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.979
K5VW89_AGABU	K5VSQ0_AGABU	K5VW89	K5VSQ0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.954
K5VW89_AGABU	K5X9R9_AGABU	K5VW89	K5X9R9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.905
K5VW89_AGABU	K5XQB0_AGABU	K5VW89	K5XQB0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.909
K5VW89_AGABU	K5Y4Y4_AGABU	K5VW89	K5Y4Y4	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	0.895
K5VW89_AGABU	K5Y7C3_AGABU	K5VW89	K5Y7C3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.880
K5VY40_AGABU	K5VSQ0_AGABU	K5VY40	K5VSQ0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.935
K5VY40_AGABU	K5X9R9_AGABU	K5VY40	K5X9R9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.917
K5VY40_AGABU	K5XQB0_AGABU	K5VY40	K5XQB0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.915
K5VY40_AGABU	K5Y4Y4_AGABU	K5VY40	K5Y4Y4	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	0.895
K5VY40_AGABU	K5Y7C3_AGABU	K5VY40	K5Y7C3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.854

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Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

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