node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KTS00188.1 | polA | NS375_06365 | NS375_18100 | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.686 |
KTS00188.1 | recA | NS375_06365 | NS375_20840 | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.670 |
KTS00188.1 | recB | NS375_06365 | NS375_00150 | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] | 0.473 |
KTS00188.1 | recC | NS375_06365 | NS375_00160 | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.454 |
KTS00188.1 | recD | NS375_06365 | NS375_00145 | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.510 |
KTS01548.1 | KTS01778.1 | NS375_00155 | NS375_00165 | Protease; Degrades small peptides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.513 |
KTS01548.1 | recB | NS375_00155 | NS375_00150 | Protease; Degrades small peptides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. | Exonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] | 0.831 |
KTS01548.1 | recC | NS375_00155 | NS375_00160 | Protease; Degrades small peptides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. | Exonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.650 |
KTS01548.1 | recD | NS375_00155 | NS375_00145 | Protease; Degrades small peptides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. | Exonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.834 |
KTS01778.1 | KTS01548.1 | NS375_00165 | NS375_00155 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protease; Degrades small peptides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. | 0.513 |
KTS01778.1 | recB | NS375_00165 | NS375_00150 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] | 0.458 |
KTS01778.1 | recC | NS375_00165 | NS375_00160 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.625 |
KTS01778.1 | recD | NS375_00165 | NS375_00145 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] | 0.460 |
KTS01778.1 | thyA | NS375_00165 | NS375_00185 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.446 |
dnaE | polA | NS375_18855 | NS375_18100 | DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.672 |
dnaE | recA | NS375_18855 | NS375_20840 | DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.526 |
dnaE | recB | NS375_18855 | NS375_00150 | DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Exonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] | 0.465 |
polA | KTS00188.1 | NS375_18100 | NS375_06365 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.686 |
polA | dnaE | NS375_18100 | NS375_18855 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.672 |
polA | recA | NS375_18100 | NS375_20840 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.981 |