node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHD19467.1 | EHD20996.1 | BrE312_0002 | BrE312_1589 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | 0.758 |
EHD19467.1 | EHD23122.1 | BrE312_0002 | BrE312_3774 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.824 |
EHD19467.1 | rcsD | BrE312_0002 | BrE312_3228 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Multi-sensor signal transduction histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. | 0.426 |
EHD19467.1 | recA | BrE312_0002 | BrE312_1008 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.943 |
EHD19467.1 | uvrB | BrE312_0002 | BrE312_1501 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] | 0.455 |
EHD20996.1 | EHD19467.1 | BrE312_1589 | BrE312_0002 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.758 |
EHD20996.1 | EHD21208.1 | BrE312_1589 | BrE312_1809 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | KEGG: eca:ECA2003 hypothetical protein. | 0.760 |
EHD20996.1 | EHD22831.1 | BrE312_1589 | BrE312_3474 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | Transcriptional antiterminator, Rof; PFAM: Modulator of Rho-dependent transcription termination; KEGG: pct:PC1_0960 Rho-binding antiterminator. | 0.767 |
EHD20996.1 | EHD23122.1 | BrE312_1589 | BrE312_3774 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.767 |
EHD20996.1 | EHD23293.1 | BrE312_1589 | BrE312_3965 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | PFAM: Virulence factor, haemolysin regulator; KEGG: pct:PC1_0451 hypothetical protein. | 0.769 |
EHD20996.1 | ftsN | BrE312_1589 | BrE312_4226 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.755 |
EHD20996.1 | lpoB | BrE312_1589 | BrE312_1642 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | Membrane lipoprotein lipid attachment site; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. | 0.769 |
EHD20996.1 | rcsD | BrE312_1589 | BrE312_3228 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | Multi-sensor signal transduction histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. | 0.755 |
EHD20996.1 | recA | BrE312_1589 | BrE312_1008 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.840 |
EHD20996.1 | uvrB | BrE312_1589 | BrE312_1501 | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] | 0.794 |
EHD21208.1 | EHD20996.1 | BrE312_1809 | BrE312_1589 | KEGG: eca:ECA2003 hypothetical protein. | PFAM: DNA helicase, UvrD/REP type; KEGG: eca:ECA1756 DNA helicase IV. | 0.760 |
EHD21208.1 | EHD22831.1 | BrE312_1809 | BrE312_3474 | KEGG: eca:ECA2003 hypothetical protein. | Transcriptional antiterminator, Rof; PFAM: Modulator of Rho-dependent transcription termination; KEGG: pct:PC1_0960 Rho-binding antiterminator. | 0.774 |
EHD21208.1 | EHD23122.1 | BrE312_1809 | BrE312_3774 | KEGG: eca:ECA2003 hypothetical protein. | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.760 |
EHD21208.1 | EHD23293.1 | BrE312_1809 | BrE312_3965 | KEGG: eca:ECA2003 hypothetical protein. | PFAM: Virulence factor, haemolysin regulator; KEGG: pct:PC1_0451 hypothetical protein. | 0.749 |
EHD21208.1 | ftsN | BrE312_1809 | BrE312_4226 | KEGG: eca:ECA2003 hypothetical protein. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.732 |