node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHD20161.1 | EHD21443.1 | BrE312_0717 | BrE312_2057 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.595 |
EHD20161.1 | EHD21444.1 | BrE312_0717 | BrE312_2058 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.600 |
EHD20161.1 | cobB | BrE312_0717 | BrE312_1656 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | KEGG: pct:PC1_2473 NAD-dependent deacetylase; HAMAP: NAD-dependent deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; Belongs to the sirtuin family. Class III subfamily. | 0.626 |
EHD20161.1 | nadD | BrE312_0717 | BrE312_3149 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.545 |
EHD20161.1 | nadE | BrE312_0717 | BrE312_2298 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.553 |
EHD20161.1 | nadK | BrE312_0717 | BrE312_3683 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.640 |
EHD21443.1 | EHD20161.1 | BrE312_2057 | BrE312_0717 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | 0.595 |
EHD21443.1 | EHD21444.1 | BrE312_2057 | BrE312_2058 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
EHD21443.1 | cobB | BrE312_2057 | BrE312_1656 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | KEGG: pct:PC1_2473 NAD-dependent deacetylase; HAMAP: NAD-dependent deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; Belongs to the sirtuin family. Class III subfamily. | 0.737 |
EHD21443.1 | ilvC | BrE312_2057 | BrE312_0240 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.552 |
EHD21443.1 | nadD | BrE312_2057 | BrE312_3149 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.734 |
EHD21443.1 | nadE | BrE312_2057 | BrE312_2298 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.715 |
EHD21443.1 | nadK | BrE312_2057 | BrE312_3683 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.786 |
EHD21443.1 | nudJ | BrE312_2057 | BrE312_2350 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | PFAM: NUDIX hydrolase domain; KEGG: pct:PC1_1870 NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.604 |
EHD21443.1 | rpoC | BrE312_2057 | BrE312_4198 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.639 |
EHD21443.1 | sthA | BrE312_2057 | BrE312_4216 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.758 |
EHD21444.1 | EHD20161.1 | BrE312_2058 | BrE312_0717 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: pct:PC1_3566 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. | 0.600 |
EHD21444.1 | EHD21443.1 | BrE312_2058 | BrE312_2057 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.999 |
EHD21444.1 | cobB | BrE312_2058 | BrE312_1656 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | KEGG: pct:PC1_2473 NAD-dependent deacetylase; HAMAP: NAD-dependent deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; Belongs to the sirtuin family. Class III subfamily. | 0.705 |
EHD21444.1 | nadD | BrE312_2058 | BrE312_3149 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.715 |