node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHD23297.1 | fmt | BrE312_3969 | BrE312_0465 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.821 |
EHD23297.1 | folD | BrE312_3969 | BrE312_1256 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.877 |
EHD23297.1 | glpG | BrE312_3969 | BrE312_0355 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Rhomboid protease glpG; Rhomboid-type serine protease that catalyzes intramembrane proteolysis. | 0.700 |
EHD23297.1 | glyA | BrE312_3969 | BrE312_1135 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.645 |
EHD23297.1 | hemA | BrE312_3969 | BrE312_2050 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.683 |
EHD23297.1 | pheT | BrE312_3969 | BrE312_2302 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: eca:ECA2417 phenylalanyl-tRNA synthetase subunit beta. | 0.669 |
EHD23297.1 | purD | BrE312_3969 | BrE312_4181 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: pct:PC1_0224 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.720 |
EHD23297.1 | purH | BrE312_3969 | BrE312_4180 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional purine biosynthesis protein purH; KEGG: pwa:Pecwa_0229 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.760 |
EHD23297.1 | purN | BrE312_3969 | BrE312_3207 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.800 |
EHD23297.1 | purT | BrE312_3969 | BrE312_2448 | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.727 |
fmt | EHD23297.1 | BrE312_0465 | BrE312_3969 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.821 |
fmt | folD | BrE312_0465 | BrE312_1256 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
fmt | glyA | BrE312_0465 | BrE312_1135 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.781 |
fmt | pheT | BrE312_0465 | BrE312_2302 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: eca:ECA2417 phenylalanyl-tRNA synthetase subunit beta. | 0.853 |
fmt | purD | BrE312_0465 | BrE312_4181 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: pct:PC1_0224 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.773 |
fmt | purH | BrE312_0465 | BrE312_4180 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Bifunctional purine biosynthesis protein purH; KEGG: pwa:Pecwa_0229 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.807 |
fmt | purN | BrE312_0465 | BrE312_3207 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.818 |
folD | EHD23297.1 | BrE312_1256 | BrE312_3969 | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Manually curated; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ddd:Dda3937_02679 putative ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.877 |
folD | fmt | BrE312_1256 | BrE312_0465 | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.943 |
folD | glyA | BrE312_1256 | BrE312_1135 | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |