| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHD19467.1 | EHD23259.1 | BrE312_0002 | BrE312_3925 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | 0.509 |
| EHD19467.1 | gyrA | BrE312_0002 | BrE312_3231 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.484 |
| EHD19467.1 | metG | BrE312_0002 | BrE312_3067 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.524 |
| EHD19467.1 | parE | BrE312_0002 | BrE312_4092 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.707 |
| EHD19467.1 | pheT | BrE312_0002 | BrE312_2302 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: eca:ECA2417 phenylalanyl-tRNA synthetase subunit beta. | 0.569 |
| EHD19467.1 | polA | BrE312_0002 | BrE312_4417 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
| EHD19467.1 | recF | BrE312_0002 | BrE312_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.932 |
| EHD23191.1 | EHD23259.1 | BrE312_3849 | BrE312_3925 | KEGG: xbo:XBJ1_1862 hypothetical protein. | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | 0.610 |
| EHD23191.1 | parE | BrE312_3849 | BrE312_4092 | KEGG: xbo:XBJ1_1862 hypothetical protein. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.642 |
| EHD23191.1 | polA | BrE312_3849 | BrE312_4417 | KEGG: xbo:XBJ1_1862 hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.647 |
| EHD23259.1 | EHD19467.1 | BrE312_3925 | BrE312_0002 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.509 |
| EHD23259.1 | EHD23191.1 | BrE312_3925 | BrE312_3849 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | KEGG: xbo:XBJ1_1862 hypothetical protein. | 0.610 |
| EHD23259.1 | gyrA | BrE312_3925 | BrE312_3231 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.526 |
| EHD23259.1 | metG | BrE312_3925 | BrE312_3067 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.567 |
| EHD23259.1 | parC | BrE312_3925 | BrE312_4083 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.526 |
| EHD23259.1 | parE | BrE312_3925 | BrE312_4092 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.610 |
| EHD23259.1 | pheT | BrE312_3925 | BrE312_2302 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: eca:ECA2417 phenylalanyl-tRNA synthetase subunit beta. | 0.553 |
| EHD23259.1 | polA | BrE312_3925 | BrE312_4417 | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.803 |
| gyrA | EHD19467.1 | BrE312_3231 | BrE312_0002 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.484 |
| gyrA | EHD23259.1 | BrE312_3231 | BrE312_3925 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 6-deoxyerythronolide-B synthase., NADPH:quinone reductase; KEGG: eca:ECA0603 type I polyketide synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Acyl transferase; Phosphopantetheine-binding; Beta-ketoacyl synthase, C-terminal; Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; Short-chain dehydrogenase/reductase SDR. | 0.526 |
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