STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rdgBNon-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.964
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.951
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
    0.914
NAMH_0531
Xanthine guanine phosphoribosyl transferase; Identified by match to protein family HMM PF00156.
  
 
  0.902
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
NAMH_0111
Phosphodiesterase; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040.
  
  
 0.812
NAMH_1435
Putative periplasmic protein.
       0.773
NAMH_1436
Putative periplasmic protein.
       0.773
NAMH_1437
Diguanylate cyclase/phosphodiesterase; Identified by match to protein family HMM PF00563; match to protein family HMM PF00990.
       0.686
nusG
Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination.
   
    0.649
Your Current Organism:
Nautilia profundicola
NCBI taxonomy Id: 598659
Other names: N. profundicola AmH, Nautilia profundicola AmH, Nautilia profundicola str. AmH, Nautilia profundicola strain AmH, Nautilia sp. AmH, epsilon proteobacterium AmH
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