node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NAMH_0243 | NAMH_1227 | NAMH_0243 | NAMH_1227 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | 0.900 |
NAMH_0243 | ilvN | NAMH_0243 | NAMH_0810 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.902 |
NAMH_0243 | leuA | NAMH_0243 | NAMH_0139 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.911 |
NAMH_0243 | leuC | NAMH_0243 | NAMH_1751 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.803 |
NAMH_0243 | leuD | NAMH_0243 | NAMH_1247 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.803 |
NAMH_0243 | ppsA | NAMH_0243 | NAMH_0766 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.913 |
NAMH_0243 | pyk | NAMH_0243 | NAMH_0548 | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.917 |
NAMH_1227 | NAMH_0243 | NAMH_1227 | NAMH_0243 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | PorB subunit of pyruvate:flavodoxin oxidoreductase; Identified by match to protein family HMM PF02775. | 0.900 |
NAMH_1227 | ilvN | NAMH_1227 | NAMH_0810 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.911 |
NAMH_1227 | leuA | NAMH_1227 | NAMH_0139 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.911 |
NAMH_1227 | leuC | NAMH_1227 | NAMH_1751 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.803 |
NAMH_1227 | leuD | NAMH_1227 | NAMH_1247 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.803 |
NAMH_1227 | ppsA | NAMH_1227 | NAMH_0766 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.913 |
NAMH_1227 | pyk | NAMH_1227 | NAMH_0548 | OorB subunit of 2-oxoglutarate:acceptor oxidoreductase; Identified by match to protein family HMM PF02775. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.919 |
ilvC | ilvD | NAMH_1150 | NAMH_1743 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.996 |
ilvC | ilvN | NAMH_1150 | NAMH_0810 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.996 |
ilvC | leuA | NAMH_1150 | NAMH_0139 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.945 |
ilvC | leuB | NAMH_1150 | NAMH_1248 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.941 |
ilvC | leuC | NAMH_1150 | NAMH_1751 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.981 |
ilvC | leuD | NAMH_1150 | NAMH_1247 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.946 |