STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (171 aa)    
Predicted Functional Partners:
WDR1
WD repeat domain 1.
   
 
 0.802
LIMK2
LIM domain kinase 2.
   
 0.800
LIMK1
LIM domain kinase 1.
   
 0.800
CAP1
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 0.704
CAP2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 0.704
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 
 0.690
TWF1
Twinfilin actin binding protein 1.
    
 
 0.661
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.648
ACTR1A
Actin related protein 1A.
   
 
 0.604
PFN2
Profilin; Belongs to the profilin family.
   
 0.580
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.