Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccrd_001281Protein kinase, ATP binding site-containing protein; Belongs to the protein kinase superfamily. (289 aa)    
Predicted Functional Partners:
Ccrd_026272
DNA helicase.
    
   0.678
Ccrd_025941
DNA helicase; Belongs to the MCM family.
    
   0.678
Ccrd_008928
Origin recognition complex, subunit 5.
    
   0.678
Ccrd_004748
DNA helicase; Belongs to the MCM family.
    
   0.678
Ccrd_021765
Uncharacterized protein.
    
   0.678
Ccrd_010624
Origin recognition complex, subunit 2.
    
   0.678
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
    
   0.678
Ccrd_014305
Origin recognition complex, subunit 3.
    
   0.678
Ccrd_003872
AAA+ ATPase domain-containing protein.
    
   0.647
Ccrd_012204
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
   0.647
Your Current Organism:
Cynara cardunculus
NCBI taxonomy Id: 59895
Other names: C. cardunculus var. scolymus, Cynara cardunculus Scolymus Group, Cynara cardunculus subsp. scolymus, Cynara cardunculus subsp. scolymus (L.) Hayek, Cynara cardunculus var. scolymus, Cynara cardunculus var. scolymus (L.) Fiori, Cynara scolymus, Cynara scolymus L., artichoke, globe artichoke
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