Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rpaBTwo-component response regulator; Alternative locus ID: PMED4_01401. (248 aa)    
Predicted Functional Partners:
nblS
Two-component sensor histidine kinase; Alternative locus ID: PMED4_15091.
 
 0.975
sasA
Two-component sensor histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.
 
 
 0.900
phoR
Two-component sensor histidine kinase, phosphate sensing; Alternative locus ID: PMED4_07801.
 
 
 0.873
kaiC
Possible circadian clock protein KaiC; Core component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiBC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family.
   
  
 0.834
plsX
Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity).
     
 0.821
kaiB
Possible circadian oscillation regulator KaiB; Probable component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. In the complex, it may affect the phosphorylation status of KaiC.
   
  
 0.742
fabH
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
     
 0.687
lpdA
Putative dihydrolipoamide dehydrogenase; Alternative locus ID: PMED4_14641.
      
 0.679
fabD
Malonyl coenzyme A-acyl carrier protein transacylase; Alternative locus ID: PMED4_01431.
     
 0.661
plsC
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase; Alternative locus ID: PMED4_01441.
       0.655
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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