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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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[Homology]
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menFIsochorismate synthase; Alternative locus ID: PMED4_01831. (465 aa)    
Predicted Functional Partners:
menD
Menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.989
menE
Probable O-succinylbenzoic acid--CoA ligase (OSB-CoA synthetase); Alternative locus ID: PMED4_01801.
 
  
 0.977
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.906
PMM1676
Conserved hypothetical protein; Alternative locus ID: PMED4_18861.
     
 0.904
trpE
Anthranilate synthase component I and chorismate binding enzyme; Definite assignment; Alternative locus ID: PMED4_17871.
  
  
0.868
PMM0636
Isochorismatase hydrolase family; Alternative locus ID: PMED4_06861.
  
  
 0.850
menA
1,4-dihydroxy-2-naphthoate (DHNA) octaprenyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily.
 
  
 0.840
menC
Putative O-succinylbenzoate synthase; Alternative locus ID: PMED4_01811; Belongs to the mandelate racemase/muconate lactonizing enzyme family.
 
  
 0.835
PMM1565
Prephenate dehydrogenase; Conserved hypothetical assignment; Alternative locus ID: PMED4_17751.
     
 0.827
hisC
Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921.
   
 
  0.811
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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