STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topAProkaryotic DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...] (870 aa)    
Predicted Functional Partners:
PMM0437
Hypothetical; Alternative locus ID: PMED4_04841.
       0.866
PMM0438
Conserved hypothetical protein; Alternative locus ID: PMED4_04851.
       0.824
PMM0440
Conserved hypothetical protein; Alternative locus ID: PMED4_04871.
     
 0.816
PMM0679
Putative transcripton factor; Alternative locus ID: PMED4_07351.
  
 0.806
PMM0439
Conserved hypothetical protein; Alternative locus ID: PMED4_04861; Belongs to the UPF0284 family.
       0.805
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.797
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
  
  
 0.763
glsF,
Ferredoxin-dependent glutamate synthase, Fd-GOGAT; Alternative locus ID: PMED4_17221.
  
  
 0.738
pyrB
Aspartate carbamoyltransferase; Putative assignment; Alternative locus ID: PMED4_02381; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.727
pgi
Phosphoglucose isomerase (PGI); Alternative locus ID: PMED4_10011.
  
  
 0.726
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.