Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PMM0439Conserved hypothetical protein; Alternative locus ID: PMED4_04861; Belongs to the UPF0284 family. (385 aa)    
Predicted Functional Partners:
cbiG/cobJ
Bifunctional cbiH protien and PRECORRIN-3B C17-METHYLTRANSFERASE; Citation: Debussche et al. (1993) J. Bacteriol. 175:7430-7440; Roth et al. (1993) J. Bacteriol. 175:3303-3316; Alternative locus ID: PMED4_17351.
  
  
 0.833
PMM0440
Conserved hypothetical protein; Alternative locus ID: PMED4_04871.
  
    0.819
PMM0438
Conserved hypothetical protein; Alternative locus ID: PMED4_04851.
 
     0.815
topA
Prokaryotic DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
       0.806
PMM0437
Hypothetical; Alternative locus ID: PMED4_04841.
  
    0.735
CobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
 
 0.734
cobL
Putative precorrin-6y methylase; Citation: Blanche et al. (1992) J. Bacteriol. 174:1050-1052; Alternative locus ID: PMED4_14341.
  
  
 0.676
PMM0486
Conserved hypothetical protein; Alternative locus ID: PMED4_05351.
  
     0.621
cobU/cobP
Putative cobinamide kinase; Citation: O'Toole and Excalante-Semerena (1995) J. Biol. Chem. 270:23560-23569; Thomas et al. (2000) J. Biol. Chem. 275:27576-27586; Alternative locus ID: PMED4_09731.
  
  
 0.621
PMM1114
Conserved hypothetical protein; Alternative locus ID: PMED4_12601.
  
     0.608
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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