Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
xthAExodeoxyribonuclease III; Alternative locus ID: PMED4_05331. (281 aa)    
Predicted Functional Partners:
nth
Putative endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.991
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.856
rsuA
Putative pseudouridylate synthase specific to ribosomal small subunit; Alternative locus ID: PMED4_07111; Belongs to the pseudouridine synthase RsuA family.
  
    0.808
mutS
Putative DNA mismatch repair protein MutS family; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
      
 0.782
PMM1214
Possible phosphatase; Alternative locus ID: PMED4_13791; Belongs to the gmhB family.
   
 
 0.647
PMM0485
Conserved hypothetical protein; Alternative locus ID: PMED4_05341.
       0.642
mfd
Transcriptional-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
     
 0.630
murI
Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
      0.611
recC
Possible exodeoxyribonuclease V subunit C 125 kD polypeptide; Alternative locus ID: PMED4_12511.
     
 0.602
recB
Possible UvrD/REP helicase subunit B; Alternative locus ID: PMED4_12491.
     
 0.600
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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