| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobC | glyA | PMM0515 | PMM0258 | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
| cobC | ilvA | PMM0515 | PMM0908 | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.900 |
| cobC | spt, | PMM0515 | PMM0919 | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | Class-V aminotransferase; Alternative locus ID: PMED4_10301. | 0.904 |
| cobC | trpA | PMM0515 | PMM0572 | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| cobC | trpB | PMM0515 | PMM0164 | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.901 |
| glyA | cobC | PMM0258 | PMM0515 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | 0.923 |
| glyA | ilvA | PMM0258 | PMM0908 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
| glyA | spt, | PMM0258 | PMM0919 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Class-V aminotransferase; Alternative locus ID: PMED4_10301. | 0.917 |
| glyA | trpA | PMM0258 | PMM0572 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.933 |
| glyA | trpB | PMM0258 | PMM0164 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.931 |
| glyA | trpD/G | PMM0258 | PMM0952 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.487 |
| glyA | trpF | PMM0258 | PMM0537 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylanthranilate isomerase; Alternative locus ID: PMED4_05861; Belongs to the TrpF family. | 0.536 |
| ilvA | cobC | PMM0908 | PMM0515 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Possible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. | 0.900 |
| ilvA | glyA | PMM0908 | PMM0258 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
| ilvA | spt, | PMM0908 | PMM0919 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Class-V aminotransferase; Alternative locus ID: PMED4_10301. | 0.914 |
| ilvA | trpA | PMM0908 | PMM0572 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.921 |
| ilvA | trpB | PMM0908 | PMM0164 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.941 |
| ilvA | trpC | PMM0908 | PMM1297 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Indole-3-glycerol phosphate synthase; Putative assignment; Alternative locus ID: PMED4_14631; Belongs to the TrpC family. | 0.469 |
| ilvA | trpE | PMM0908 | PMM1577 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Anthranilate synthase component I and chorismate binding enzyme; Definite assignment; Alternative locus ID: PMED4_17871. | 0.552 |
| pabA | trpA | PMM0184 | PMM0572 | Para-aminobenzoate synthase component II; CONTAINS 1 TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAIN; Citation: Kapland and Nichols (1983) J. Mol. Biol. 168:451-468; Tran et al. (1990) J. Bacteriol. 172:397-410; Alternative locus ID: PMED4_01901. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.933 |
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