| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PMM0279 | murI | PMM0279 | PMM0617 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.904 |
| PMM0279 | purQ | PMM0279 | PMM0780 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.497 |
| PMM0614 | PMM0615 | PMM0614 | PMM0615 | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | Possible nitrilase; Alternative locus ID: PMED4_06641. | 0.736 |
| PMM0614 | PMM0616 | PMM0614 | PMM0616 | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | 0.736 |
| PMM0614 | murI | PMM0614 | PMM0617 | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.736 |
| PMM0614 | sds | PMM0614 | PMM0618 | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | Polyprenyl synthetase; Alternative locus ID: PMED4_06671; Belongs to the FPP/GGPP synthase family. | 0.677 |
| PMM0615 | PMM0614 | PMM0615 | PMM0614 | Possible nitrilase; Alternative locus ID: PMED4_06641. | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | 0.736 |
| PMM0615 | PMM0616 | PMM0615 | PMM0616 | Possible nitrilase; Alternative locus ID: PMED4_06641. | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | 0.819 |
| PMM0615 | murI | PMM0615 | PMM0617 | Possible nitrilase; Alternative locus ID: PMED4_06641. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.818 |
| PMM0615 | sds | PMM0615 | PMM0618 | Possible nitrilase; Alternative locus ID: PMED4_06641. | Polyprenyl synthetase; Alternative locus ID: PMED4_06671; Belongs to the FPP/GGPP synthase family. | 0.745 |
| PMM0616 | PMM0614 | PMM0616 | PMM0614 | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. | 0.736 |
| PMM0616 | PMM0615 | PMM0616 | PMM0615 | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | Possible nitrilase; Alternative locus ID: PMED4_06641. | 0.819 |
| PMM0616 | murI | PMM0616 | PMM0617 | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.856 |
| PMM0616 | sds | PMM0616 | PMM0618 | Cell wall hydrolase/autolysin; Alternative locus ID: PMED4_06651. | Polyprenyl synthetase; Alternative locus ID: PMED4_06671; Belongs to the FPP/GGPP synthase family. | 0.745 |
| glnA | murI | PMM0920 | PMM0617 | Glutamine synthetase, glutamate--ammonia ligase; Alternative locus ID: PMED4_10311. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.862 |
| glnA | purQ | PMM0920 | PMM0780 | Glutamine synthetase, glutamate--ammonia ligase; Alternative locus ID: PMED4_10311. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.906 |
| glnA | spt, | PMM0920 | PMM0919 | Glutamine synthetase, glutamate--ammonia ligase; Alternative locus ID: PMED4_10311. | Class-V aminotransferase; Alternative locus ID: PMED4_10301. | 0.588 |
| murD | murI | PMM1364 | PMM0617 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.972 |
| murD | purQ | PMM1364 | PMM0780 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.900 |
| murI | PMM0279 | PMM0617 | PMM0279 | Putative aspartate and glutamate racemases:Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.904 |