STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
folPPutative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa)    
Predicted Functional Partners:
folB
Possible dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
 
 0.998
folK
Possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Citation: Talarico et al. (1992) J. Bacteriol. 174:5971-5977; Alternative locus ID: PMED4_02921.
 
 
 0.997
folC
Putuative bifunctional Dihydrofolate/Folylpolyglutamate synthase; Citation: Bogner et al. (1987) J. Biol. Chem. 262:12337-12343; Alternative locus ID: PMED4_14691; Belongs to the folylpolyglutamate synthase family.
 
 0.997
folE
Putative GTP cyclohydrolase I; Citation: Katzenmeier et al. (1991) Biol. Chem. Hoppe-Seyler 372:991-997; Alternative locus ID: PMED4_05851.
 
  
 0.968
tpi,
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
 0.858
PMM0828
S4 domain; Alternative locus ID: PMED4_09221.
       0.657
PMM1693
Aminotransferases class-IV; Hypothetical aminotransferase; Alternative locus ID: PMED4_19041.
 
 
 0.654
pabA
Para-aminobenzoate synthase component II; CONTAINS 1 TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAIN; Citation: Kapland and Nichols (1983) J. Mol. Biol. 168:451-468; Tran et al. (1990) J. Bacteriol. 172:397-410; Alternative locus ID: PMED4_01901.
 
  
 0.588
PMM0827
ABC transporter, possibly multidrug efflux; Alternative locus ID: PMED4_09211.
       0.563
ribH
Putative 6,7-dimethyl-8-ribityllumazine synthase or riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
   
  
 0.557
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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