Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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ribA/ribBPossible GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (577 aa)    
Predicted Functional Partners:
ribE
Putative Riboflavin synthase alpha chain; Citation: Eberhardt et al. (1996) Eur. J. Biochem. 242:712-719; Alternative locus ID: PMED4_04891.
 
 0.999
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 0.999
ribH
Putative 6,7-dimethyl-8-ribityllumazine synthase or riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
folE
Putative GTP cyclohydrolase I; Citation: Katzenmeier et al. (1991) Biol. Chem. Hoppe-Seyler 372:991-997; Alternative locus ID: PMED4_05851.
 
 
 0.958
ribG
RibD/ribG C-terminal domain; Alternative locus ID: PMED4_01111.
  
 
 0.899
rps2,
30S ribosomal protein S2; Alternative locus ID: PMED4_08381; Belongs to the universal ribosomal protein uS2 family.
   
  
 0.887
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.870
spoT
Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, (ppGpp)ase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.843
guaB
Putative IMP dehydrogenase; Alternative locus ID: PMED4_12081.
  
  
 0.835
ribF
Putative riboflavin kinase/FAD synthase; Citation: Gupta et al. (1999) FEMS Microbiol Lett 179:501-506; Alternative locus ID: PMED4_14391; Belongs to the ribF family.
     
 0.809
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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