node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | PMM0796 | PMM0281 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | 0.969 |
hisA | hisC | PMM0796 | PMM0186 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. | 0.805 |
hisA | hisC/cobC | PMM0796 | PMM0198 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979; Alternative locus ID: PMED4_02041. | 0.808 |
hisA | hisD | PMM0796 | PMM1488 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.974 |
hisA | hisF | PMM0796 | PMM0430 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.992 |
hisA | hisG | PMM0796 | PMM0560 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.953 |
hisA | hisH | PMM0796 | PMM1060 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | PMM0796 | PMM0578 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | Phosphoribosyl-AMP cyclohydrolase; Alternative locus ID: PMED4_06271; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | purH | PMM0796 | PMM0266 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | AICARFT/IMPCHase bienzyme:Methylglyoxal synthase-like domain; Alternative locus ID: PMED4_02711. | 0.514 |
hisB | hisA | PMM0281 | PMM0796 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | 0.969 |
hisB | hisC | PMM0281 | PMM0186 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. | 0.998 |
hisB | hisC/cobC | PMM0281 | PMM0198 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979; Alternative locus ID: PMED4_02041. | 0.839 |
hisB | hisD | PMM0281 | PMM1488 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisF | PMM0281 | PMM0430 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisB | hisG | PMM0281 | PMM0560 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.957 |
hisB | hisH | PMM0281 | PMM1060 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.996 |
hisB | hisI | PMM0281 | PMM0578 | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | Phosphoribosyl-AMP cyclohydrolase; Alternative locus ID: PMED4_06271; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisC | hisA | PMM0186 | PMM0796 | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE; Alternative locus ID: PMED4_08821. | 0.805 |
hisC | hisB | PMM0186 | PMM0281 | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PMED4_02861. | 0.998 |
hisC | hisD | PMM0186 | PMM1488 | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |