STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sasATwo-component sensor histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs. (372 aa)    
Predicted Functional Partners:
rpaA
Two-component response regulator; Alternative locus ID: PMED4_01341.
 
 0.985
PMM1619
Two-component response regulator; Alternative locus ID: PMED4_18291.
 
 
 0.922
rpaB
Two-component response regulator; Alternative locus ID: PMED4_01401.
 
 
 0.916
PMM1369
GAF domain; Alternative locus ID: PMED4_15401.
    
 0.903
kaiC
Possible circadian clock protein KaiC; Core component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiBC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family.
   
 
 0.876
phoB
Two-component response regulator, phosphate; Alternative locus ID: PMED4_07791.
 
 
 0.864
PMM0169
Two-component response regulator; Alternative locus ID: PMED4_01751.
 
 0.803
PMM1113
Two-component response regulator; Alternative locus ID: PMED4_12591.
  
 
 0.803
PMM1078
Conserved hypothetical; Alternative locus ID: PMED4_12241.
       0.653
mutS,fdv
Putative DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).
  
  
 0.565
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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