Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gldAPutative glycerol dehydrogenase; Alternative locus ID: PMED4_12331. (364 aa)    
Predicted Functional Partners:
todF
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase; Alternative locus ID: PMED4_12321.
  
    0.834
clpC
ClpC; Regulatory subunit of ATP-dependent Clp protease; Alternative locus ID: PMED4_12341; Belongs to the ClpA/ClpB family.
  
    0.804
atp1
Possible ATP synthase subunit 1; Alternative locus ID: PMED4_16661.
      
 0.643
rpl17,
50S ribosomal protein L17; Alternative locus ID: PMED4_17441.
      
 0.643
gyrA
DNA gyrase/topoisomerase IV, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depend [...]
      
 0.616
PMM1089
Putative ribosomal-protein-alanine acetyltransferase; Alternative locus ID: PMED4_12351.
       0.549
ndhA
Putative respiratory-chain NADH dehydrogenase subunit; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
      
 0.527
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
      
 0.514
pykF
Pyruvate kinase; Alternative locus ID: PMED4_10231; Belongs to the pyruvate kinase family.
      
 0.482
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
   
 0.477
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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