| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BioB | PMM1094 | PMM1093 | PMM1094 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | 0.818 |
| BioB | dacA | PMM1093 | PMM1091 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.818 |
| BioB | lysA | PMM1093 | PMM1090 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.771 |
| BioB | uppS | PMM1093 | PMM1092 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.818 |
| PMM1085 | dxr | PMM1085 | PMM1142 | Phosphatidate cytidylyltransferase; Alternative locus ID: PMED4_12311; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.632 |
| PMM1085 | uppS | PMM1085 | PMM1092 | Phosphatidate cytidylyltransferase; Alternative locus ID: PMED4_12311; Belongs to the CDS family. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.967 |
| PMM1094 | BioB | PMM1094 | PMM1093 | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.818 |
| PMM1094 | dacA | PMM1094 | PMM1091 | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.818 |
| PMM1094 | lysA | PMM1094 | PMM1090 | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.742 |
| PMM1094 | uppS | PMM1094 | PMM1092 | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.818 |
| crtB,pys | crtE | PMM0143 | PMM1070 | Squalene and phytoene synthases; Alternative locus ID: PMED4_01491. | Polyprenyl synthetase; Alternative locus ID: PMED4_12161; Belongs to the FPP/GGPP synthase family. | 0.992 |
| crtB,pys | dxr | PMM0143 | PMM1142 | Squalene and phytoene synthases; Alternative locus ID: PMED4_01491. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.429 |
| crtB,pys | uppS | PMM0143 | PMM1092 | Squalene and phytoene synthases; Alternative locus ID: PMED4_01491. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.856 |
| crtE | crtB,pys | PMM1070 | PMM0143 | Polyprenyl synthetase; Alternative locus ID: PMED4_12161; Belongs to the FPP/GGPP synthase family. | Squalene and phytoene synthases; Alternative locus ID: PMED4_01491. | 0.992 |
| crtE | dxr | PMM1070 | PMM1142 | Polyprenyl synthetase; Alternative locus ID: PMED4_12161; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.640 |
| crtE | uppS | PMM1070 | PMM1092 | Polyprenyl synthetase; Alternative locus ID: PMED4_12161; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.972 |
| dacA | BioB | PMM1091 | PMM1093 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.818 |
| dacA | PMM1094 | PMM1091 | PMM1094 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | Conserved hypothetical protein; Alternative locus ID: PMED4_12401; Belongs to the UPF0176 family. | 0.818 |
| dacA | lysA | PMM1091 | PMM1090 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.833 |
| dacA | uppS | PMM1091 | PMM1092 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.882 |