| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PMM0528 | apt | PMM0528 | PMM1122 | DUF152; Alternative locus ID: PMED4_05771; Belongs to the multicopper oxidase YfiH/RL5 family. | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.905 |
| PMM0528 | surE | PMM0528 | PMM1271 | DUF152; Alternative locus ID: PMED4_05771; Belongs to the multicopper oxidase YfiH/RL5 family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| PMM1565 | apt | PMM1565 | PMM1122 | Prephenate dehydrogenase; Conserved hypothetical assignment; Alternative locus ID: PMED4_17751. | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.658 |
| adk | apt | PMM1539 | PMM1122 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.942 |
| adk | guaA | PMM1539 | PMM0037 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Glutamine amidotransferase class-I:GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.608 |
| adk | purA,adeK | PMM1539 | PMM0506 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.417 |
| adk | purB | PMM1539 | PMM1465 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; Frameshift; similar to P9515_16441; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.940 |
| adk | surE | PMM1539 | PMM1271 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.923 |
| apt | PMM0528 | PMM1122 | PMM0528 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | DUF152; Alternative locus ID: PMED4_05771; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.905 |
| apt | PMM1565 | PMM1122 | PMM1565 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Prephenate dehydrogenase; Conserved hypothetical assignment; Alternative locus ID: PMED4_17751. | 0.658 |
| apt | adk | PMM1122 | PMM1539 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.942 |
| apt | guaA | PMM1122 | PMM0037 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase class-I:GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.831 |
| apt | hisF | PMM1122 | PMM0430 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.814 |
| apt | hisH | PMM1122 | PMM1060 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.806 |
| apt | purA,adeK | PMM1122 | PMM0506 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.722 |
| apt | purB | PMM1122 | PMM1465 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Frameshift; similar to P9515_16441; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.967 |
| apt | purH | PMM1122 | PMM0266 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | AICARFT/IMPCHase bienzyme:Methylglyoxal synthase-like domain; Alternative locus ID: PMED4_02711. | 0.953 |
| apt | surE | PMM1122 | PMM1271 | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| guaA | adk | PMM0037 | PMM1539 | Glutamine amidotransferase class-I:GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.608 |
| guaA | apt | PMM0037 | PMM1122 | Glutamine amidotransferase class-I:GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.831 |
